Fluorescent agent concentration measuring apparatus, dose control apparatus, administration system, fluorescent agent concentration measuring method, and dose control method

• US 8,395,775 B2
• Filed: 05/11/2011
• Issued: 03/12/2013
• Est. Priority Date: 01/11/2005
• Status: Active Grant

• Current Assignee: Olympus Corporation
• Original Assignee: Olympus Corporation
• Inventors: Okawa, Atsushi
• Primary Examiner(s): STAFIRA, MICHAEL PATRICK
• Application Number:
  US13/105,515
• Publication Number:
  US 20110213562A1
• Time in Patent Office: 671 Days
• Field of Search: 356432-436
• US Class Current: 356/432
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2205/3306 Optical measuring means
• CPC Class Codes: A61M 5/16836 by sensing tissue properties at the infusion site, e.g. for detecting infiltration detecting tissue temperature for diagnostic purposes A61M39/0247
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: G01N 21/645 Specially adapted constructive features of fluorimeters
• CPC Class Codes: G01N 21/6486 Measuring fluorescence of biological material, e.g. DNA, RNA, cells G01N21/6428 takes precedence

Abstract

A fluorescent agent accumulation concentration measuring apparatus is configured to include a single-wavelength LED to radiate excitation light to a test bottle loaded in the inside, a barrier filter to transmit only fluorescence from the test bottle, a photoreceptor to receive the fluorescence through the barrier filter and output an electric signal, a detection processing circuit to conduct signal processing of the electric signal from the photoreceptor and detect the fluorescence intensity, and an operation circuit 26 to compare the detection result from the detection processing circuit with an analytical pattern stored in a pattern storage portion and calculate the peak time of the accumulation concentration in a tissue of a sample in the test bottle.

Claims

1. A fluorescent agent concentration measuring apparatus comprising:

an excitation light source to radiate excitation light to a sample containing a body fluid taken from a living body administered with a fluorescent drug, the excitation light allowing the drug to emit fluorescence;

a fluorescence detection portion to detect the fluorescence;

a fluorescent agent concentration calculation portion to calculate the concentration of the drug in the living body, based on a detection signal from the fluorescence detection portion;

a curve data storage portion to pre-store, as a pattern, curve data that indicates a relation of concentrations of the drug in the living body at a plurality of times of day; and

a peak time estimation portion configured to compare the elapsed time after administration of the drug to the living body and the calculated concentration of the drug with the pattern pre-stored in the curve data storage portion and configured to estimate the elapsed time after administration the concentration of the drug in the living body is at a peak.

2. The fluorescent agent concentration measuring apparatus according to claim 1, further comprising a container loading portion to removably dispose a container including the sample solution on an optical path of the excitation light.

3. The fluorescent agent concentration measuring apparatus according to claim 2, further comprising a light shield portion to shield the container loaded in the container loading portion from the external light.

4. The fluorescent agent concentration measuring apparatus according to claim 1, wherein, in a optical path from the excitation light source to the fluorescence detection portion, one or more optical members and one or more optical filters are disposed, wherein each of the one or more optical members and each of the one or more optical filters have a predetermined refraction index constant in a plane orthogonal to an optical axis of the optical path.

5. The fluorescent agent concentration measuring apparatus according to claim 4, wherein each of the one or more optical members has a different predetermined refraction index.

6. The fluorescent agent concentration measuring apparatus according to claim 4, wherein each of the one or more optical filters has a different predetermined refraction index.

7. The fluorescent agent concentration measuring apparatus according to claim 1, wherein the excitation light source is configured to include a single wavelength.