Device, system and method for automatic detection of contractile activity in an image frame

• US 8,396,327 B2
• Filed: 03/13/2007
• Issued: 03/12/2013
• Est. Priority Date: 03/13/2006
• Status: Active Grant

• Current Assignee: Given Imaging Limited (Medtronic Plc)
• Original Assignee: Given Imaging Limited (Medtronic Plc)
• Inventors: Spyridonos, Panagiota, Vilarino, Fernando, Vitria, Jordi, Radeva, Petia, Azpiroz, Fernando, Malagelada, Juan
• Primary Examiner(s): Kassa, Yosef
• Application Number:
  US12/282,704
• Publication Number:
  US 20110044515A1
• Time in Patent Office: 2,191 Days
• Field of Search: 382/128, 382/130, 382/131, 382/132, 382/278, 382/286, 128/922
• US Class Current: 382/286
• CPC Class Codes: A61B 1/000094 extracting biological structures
• CPC Class Codes: A61B 1/00045 Display arrangement
• CPC Class Codes: A61B 1/041 Capsule endoscopes for imaging
• CPC Class Codes: A61B 5/00 Measuring for diagnostic purposes radiation diagnosis A61B6/00; diagnosis by ultrasonic, sonic or infrasonic waves A61B8/00; Identification of persons
• CPC Class Codes: G06T 2207/10016 Video; Image sequence
• CPC Class Codes: G06T 2207/20036 Morphological image processing
• CPC Class Codes: G06T 2207/20044 Skeletonization; Medial axis transform
• CPC Class Codes: G06T 2207/30028 Colon; Small intestine
• CPC Class Codes: G06T 7/0012 Biomedical image inspection
• CPC Class Codes: G06T 7/44 using image operators, e.g. filters, edge density metrics or local histograms

Abstract

A device, system and method for automatic detection of contractile activity of a body lumen in an image frame is provided, wherein image frames during contractile activity are captured and/or image frames including contractile activity are automatically detected, such as through pattern recognition and/or feature extraction to trace image frames including contractions, e.g., with wrinkle patterns. A manual procedure of annotation of contractions, e.g. tonic contractions in capsule endoscopy, may consist of the visualization of the whole video by a specialist, and the labeling of the contraction frames. Embodiments of the present invention may be suitable for implementation in an in vivo imaging system.

Claims

1. A method for identifying image frames depicting contractile activity of an intestinal lumen comprising:

identifying a wrinkle pattern in an image frame, said wrinkle pattern including edges of a folded intestinal wall;

identifying a center of the intestinal lumen; and

determining whether the image frame depicts contractile activity.

2. The method of claim 1 further comprising determining if the wrinkle pattern is distributed in a radial way around the center of the intestinal lumen.

3. A method for identifying image frames depicting contractile activity comprising:

receiving an image frame;

identifying a wrinkle pattern in the image frame;

extracting a skeleton of the wrinkle pattern;

determining a center of the skeleton; and

determining whether the image frame depicts contractile activity.

4. The method of claim 3 wherein determining a center of the skeleton comprises automatically detecting a center of a lumen in an in-vivo image.

5. The method of claim 4 further comprising smoothing the image frames.

6. The method of claim 5 wherein the smoothing is performed by a sigma 2D Gaussian filter.

7. The method of claim 4 further comprising:

selecting an eigenvalue; and

using an eigenvector that corresponds to the eigenvalue to detect a wrinkle edge.

8. The method of claim 7 wherein the eigenvalue is the highest eigenvalue.

9. The method of claim 3 wherein determining whether the image frame depicts contractile activity is based on a sequence of frames.

10. A system to automatically identify images depicting contractile activity comprising:

an imaging device to obtain an in-vivo image;

a contractile activity detector to identify a wrinkle pattern in the image and to determine if the image depicts contractile activity.

11. The system of claim 10 wherein the imaging device is an ingestible capsule.

12. The system of claim 10 further comprising a processor to determine a center of the wrinkle pattern.

13. The system of claim 12 wherein the processor is to determine a skeleton of the wrinkle pattern.