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Electrophysiological screens for cognitive modulators

  • US 8,396,545 B2
  • Filed: 02/24/2009
  • Issued: 03/12/2013
  • Est. Priority Date: 02/25/2008
  • Status: Expired due to Fees
First Claim
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1. A method of testing a subject to predict an effect of an administered compound on the subject'"'"'s prefrontal cortex-dependent cognition, which comprises:

  • administering a compound;

    subsequently administering a stimulus that evokes an electromagnetic response in the subject'"'"'s prefrontal cortex;

    sensing at least one component of the electromagnetic response in the subject'"'"'s prefrontal cortex independent from electromagnetic responses in other areas of the brain in response to the administered stimulus both in the presence and in the absence of the compound;

    comparing the at least one component of the electromagnetic response from the prefrontal cortex evoked by the stimulus in the absence of the administered compound with the at least one component of the electromagnetic response from the prefrontal cortex evoked by the stimulus in the presence of the administered compound; and

    determining the effect of the administered compound based on the comparison.

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