Methods for treating central pain syndrome and other pain related pathologies
First Claim
1. A method of treating a symptom of central pain syndrome (CPS) in an individual in need thereof comprising electrically stimulating the zona incerta (ZI) region of the brain of an individual having CPS in an amount sufficient to increase GABAergic neuron firing, wherein the stimulating occurs at a frequency of between about 0.1 Hz to 900 Hz.
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Abstract
Central pain syndrome (CPS) is a debilitating condition that affects a large number of patients with a primary lesion or dysfunction in the central nervous system. Despite its discovery over a century ago, the pathophysiology underlying the development and maintenance of CPS is poorly understood. The present invention is drawn to novel methods of treating CPS. In certain aspects, the invention is drawn to the novel discovery of the role of the zona incerta (ZI) in CPS and methods of exploiting this novel discovery for the treatment of CPS.
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Citations
14 Claims
- 1. A method of treating a symptom of central pain syndrome (CPS) in an individual in need thereof comprising electrically stimulating the zona incerta (ZI) region of the brain of an individual having CPS in an amount sufficient to increase GABAergic neuron firing, wherein the stimulating occurs at a frequency of between about 0.1 Hz to 900 Hz.
- 8. A method of treating a hyperalgesia in an individual in need thereof comprising electrically stimulating the zona incerta (ZI) region of the brain of an individual having hyperalgesia in an amount sufficient to increase GABAergic neuron firing, wherein the stimulating occurs at a frequency of between about 0.1 Hz to 900 Hz.
Specification