Method and apparatus for substance delivery in system for supplying breathable gas

• US 8,397,716 B2
• Filed: 07/16/2010
• Issued: 03/19/2013
• Est. Priority Date: 12/12/1996
• Status: Expired due to Fees

• Current Assignee: Resmed Limited (ResMed Incorporated)
• Original Assignee: Resmed Limited (ResMed Incorporated)
• Inventors: Calluaud, Michel, Yerbury, Victor
• Primary Examiner(s): Ostrup, Clinton T
• Application Number:
  US12/837,784
• Publication Number:
  US 20100282251A1
• Time in Patent Office: 977 Days
• Field of Search: 128/203.12, 128/203.15, 128/203.16, 128/203.19, 128/200.24, 128/203.22, 128/203.25, 128/203.29, 128/204.18, 128/204.21, 128/204.22, 128/204.26, 128/205.11, 128/205.25, 128/200.21, 128/204.23
• US Class Current: 128/203.12
• CPC Class Codes: A61M 15/0065 Inhalators with dosage or measuring devices A61M15/0028 takes precedence; dosage devices incorporated in aerosol cans B65D83/52
• CPC Class Codes: A61M 15/0066 with means for varying the dose size
• CPC Class Codes: A61M 16/14 by mixing different fluids, one of them being in a liquid phase
• CPC Class Codes: A61M 16/147 the respiratory gas not passing through the liquid container
• CPC Class Codes: A61M 2016/0021 with a proportional output signal, e.g. from a thermistor
• CPC Class Codes: A61M 2016/0039 in the inspiratory circuit
• CPC Class Codes: A61M 2016/0042 in the expiratory circuit

Abstract

A substance delivery apparatus for use with a system for supplying breathable gas to a human or animal includes a sensor to measure the pressure of the supplied breathable gas and to detect inhalation by the human or animal; and a reservoir, a conduit, a pump, and a diaphragm to deliver the substance to the human or animal during inhalation at a pressure higher than the supplied pressure of the breathable gas.

Claims

1. A substance delivery apparatus for supplying a substance to a human or animal, the substance delivery apparatus comprising:

means for generating a flow of pressurized breathable gas;

means for measuring the pressure of the flow of pressurized breathable gas; and

means for delivering the substance with the flow of pressurized breathable gas to the human or animal only during inhalation, the substance being added to the flow of pressurized breathable gas at a pressure that exceeds the measured pressure of the flow of pressurized breathable gas by a predetermined pressure difference.

2. An apparatus as claimed in claim 1, further comprising means for detecting inhalation by the human or animal.

3. An apparatus as claimed in claim 2, wherein the means for detecting inhalation comprises an airflow sensor adapted to measure a volumetric flow rate of the flow of pressurized breathable gas passing through a flexible conduit in fluid communication with the means for generating the flow of pressurized breathable gas and a mask adapted to be worn by the human or animal and being adapted to generate a first input signal indicative of the breathable gas flow rate.

4. An apparatus as claimed in claim 3, further comprising a differentiating filter to derive the first signal into a second input signal indicative of acceleration or deceleration of the breathable gas to thereby indicate inhalation or exhalation respectively.

5. An apparatus as claimed in claim 1, wherein the substance is a medicinal substance in the form of a gas, mist, aerated suspension, jet, spray, or a gas mixture.

6. An apparatus as claimed in claim 1, wherein the means for delivering the substance is adapted to deliver the substance to a respiratory system of the human or animal.

7. An apparatus as claimed in claim 6, wherein the means for delivering the substance is adapted to deliver the substance to nasal airways of the human or animal.

8. An apparatus as claimed in claim 1, further including means for determining a volume of the substance to be delivered to the means for delivering the substance to the human or animal.

9. An apparatus as claimed in claim 1, wherein the means for measuring the pressure is a pressure transducer adapted to be connected to a conduit in fluid communication with the means for generating a flow of pressurized breathable gas and a patient interface adapted to be worn by the human or animal.

10. An apparatus as claimed in claim 1, wherein the means for delivering a substance is a positive displacement pump.

11. An apparatus as claimed in claim 10, wherein the positive displacement pump is a diaphragm pump.

12. An apparatus as claimed in claim 11, wherein the diaphragm pump is in fluid communication with a substance reservoir via a one-way valve adapted to allow the substance to only pass from the reservoir to the diaphragm pump.

13. An apparatus as claimed in claim 11, wherein the diaphragm pump is displaced by a linear drive.

14. An apparatus as claimed in claim 13, wherein the linear drive is an electromagnet.

15. An apparatus as claimed in claim 11, wherein a diaphragm of the diaphragm pump is displaced by a rotary to linear converter driven by a rotary drive.

16. An apparatus as claimed in claim 15, wherein the rotary drive is one of an electric direct current motor, an electric alternating current motor, a stepper motor or a brushless motor.

17. An apparatus as claimed in claim 1, wherein the means for delivering the substance is synchronized with the inhalation and an exhalation of the human or animal so that the means for delivering the substance operates in an inhalation phase during inhalation and operates in an exhalation phase during exhalation.

18. An apparatus as claimed in claim 17, wherein the means for delivering the substance is adapted to receive the substance from a reservoir during the exhalation phase and deliver the substance during the inhalation phase.

19. A substance delivery apparatus for supplying a substance to a human or animal, the substance delivery apparatus comprising:

a flow generator configured to generate a flow of pressurized breathable gas;

a pressure sensor to measure the pressure of the flow of pressurized breathable gas;

an air flow sensor adapted to measure a volumetric flow rate of the flow of pressurized breathable gas;

a positive displacement pump configured to add the substance to the flow of pressurized breathable gas at a pressure that exceeds the measured pressure of the flow of pressurized breathable gas by a predetermined pressure difference; and

a control system configured to operate the positive displacement pump,

wherein the substance is added to the flow of pressurized breathable gas only during a volumetric flow rate indicative of inhalation.

20. An apparatus as claimed in claim 19, further comprising a flexible conduit in fluid communication with the flow generator and a mask adapted to be worn by the human or animal, wherein the air flow sensor configured to measure the volumetric flow rate of the flow of pressurized breathable gas passing through the flexible conduit.

21. An apparatus as claimed in claim 20, wherein the air flow sensor is adapted to generate a first input signal indicative of the breathable gas flow rate.

22. An apparatus as claimed in claim 21, wherein the control system is configured to derive the first signal into a second input signal indicative of acceleration or deceleration of the breathable gas to thereby indicate inhalation or exhalation respectively.

23. An apparatus as claimed in claim 22, wherein the positive displacement pump is configured to operate in an exhalation phase synchronized with exhalation in which the displacement pump receives the substance from a substance reservoir and operate in an inhalation phase synchronized with inhalation in which the displacement pump add the substance to the flow of pressurized breathable gas.

24. An apparatus as claimed in claim 23, wherein the control system is configured to determine a volume of the substance to be delivered to the flow of pressurized breathable gas.

25. An apparatus as claimed in claim 24, wherein the positive displacement pump is a diaphragm pump.

26. An apparatus as claimed in claim 25, wherein the control system is configured to displace a diaphragm of the diaphragm by a distance corresponding to the determined volume of the substance to be added to the flow of pressurized breathable gas.

27. An apparatus as claimed in claim 26, wherein the diaphragm pump is in fluid communication with the substance reservoir via a one-way valve adapted to allow the substance to only pass from the substance reservoir to the diaphragm pump.

28. An apparatus as claimed in claim 27, wherein the diaphragm pump is displaced by a linear drive.

29. An apparatus as claimed in claim 28, wherein the linear drive is an electromagnet.

30. An apparatus as claimed in claim 29, wherein the diaphragm of the diaphragm pump is displaced by a rotary to linear converter driven by a rotary drive.

31. An apparatus as claimed in claim 30, wherein the rotary drive is one of an electric direct current motor, an electric alternating current motor, a stepper motor or a brushless motor.

32. A substance delivery apparatus for supplying a substance to a human or animal, the substance delivery apparatus comprising:

a flow generator configured to generate a flow of pressurized breathable gas;

a pressure sensor to measure the pressure of the flow of pressurized breathable gas;

an air flow sensor adapted to measure a volumetric flow rate of the flow of pressurized breathable gas;

a positive displacement pump configured to add the substance to the flow of pressurized breathable gas at a pressure that exceeds the measured pressure of the flow of pressurized breathable gas by a predetermined pressure difference; and

a control system configured to operate the positive displacement pump in an inhalation phase and an exhalation phase so that the positive displacement pump receives the substance during exhalation and adds the substances to the flow of pressurized breathable gas during inhalation.

33. An apparatus as claimed in claim 32, wherein the air flow sensor is adapted to generate a first input signal indicative of the breathable gas flow rate.

34. An apparatus as claimed in claim 33, wherein the control system is configured to derive the first signal into a second input signal indicative of acceleration or deceleration of the breathable gas to thereby indicate inhalation or exhalation respectively.