Electronic connector having a clamping member urging a flow cell toward an electrical circuitry with an electrically conductive membrane disposed in between

• US 8,398,418 B2
• Filed: 01/07/2011
• Issued: 03/19/2013
• Est. Priority Date: 01/07/2010
• Status: Active Grant

• Current Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Life Technologies Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Nobile, John, Roth, George, Marran, David, Mileski, William
• Primary Examiner(s): Prasad, Chandrika
• Application Number:
  US12/986,963
• Publication Number:
  US 20110217860A1
• Time in Patent Office: 802 Days
• Field of Search: 439271-274, 439/519, 439/587, 439591-593
• US Class Current: 439/271
• CPC Class Codes: G01N 27/4148 Integrated circuits therefor, e.g. fabricated by CMOS processing CMOS processing per se H01L21/82
• CPC Class Codes: Y10T 29/49147 Assembling terminal to base

Abstract

A leak resistant electrical connector configured as a fluidic barrier between a fluidics device, which may comprise a chemFET sensor, and other electrical circuitry wherein the fluidics device further comprises one or more electrical contacts conductively coupled to one or more electrical contacts associated with the electrical circuitry through the connector.

Claims

1. An electrical connector, comprising:

a conformable electrically conductive membrane disposed between a flow cell and an electrical circuitry, the conformable electrically conductive membrane defining conductive pathways between one or more electrical contacts associated with the flow cell and one or more corresponding electrical contacts associated with the electrical circuitry, the conformable electrically conductive membrane comprising an elastomeric material and columns of conductive material, the columns of conductive material defining the conductive pathways, the flow cell having one or more fluid transfer ports, and the flow cell further being associated with at least one electrical component for detecting at least one analyte within the flow cell, the conformable electrically conductive membrane defining a barrier to prevent intrusion of liquid into the electrical circuitry; and

a clamping member configured to urge the flow cell in proximity to the electrical circuitry with the conformable electrically conductive membrane disposed therebetween establishing the conductive pathways between the flow cell and the electrical circuitry while preventing fluid from contacting the electrical circuitry.

2. The electrical connector of claim 1, wherein the membrane is interposed between the flow cell and the electrical circuitry such that the flow cell and the electrical circuitry are substantially prevented from direct contact with each other.

3. The electrical connector of claim 1, wherein a conformable characteristic of the membrane accommodates surface perturbations present on the flow cell while establishing the conductive pathways between the one or more electrical contacts associated with the flow cell and the one or more corresponding electrical contacts associated with the electrical circuitry.

4. The electrical connector of claim 1, wherein a conformable characteristic of the membrane accommodates at least partial deformation of the flow cell while establishing the conductive pathways between the one or more electrical contacts associated with the flow cell and the one or more corresponding electrical contacts associated with the electrical circuitry.

5. The electrical connector of claim 1, wherein the electrical contacts associated with the flow cell and the corresponding electrical contacts associated with the electrical circuitry comprise a material resistant to galvanic corrosion.

6. The electrical connector of claim 1, wherein the electrical components comprise one or more chemical field effect transistor (chemFET) sensors.

7. The electrical connector of claim 1, wherein the conformable electrically conductive membrane is to isolate the conductive pathways from liquid intrusion.

8. A method for establishing an electrical connection between a flow cell and an electrical circuitry, the method comprising:

positioning a conformable electrically conductive membrane in proximity to the flow cell and the electrical circuitry, the flow cell having one or more fluid transfer ports, and the flow cell further being associated with at least one electrical component for detecting at least one analyte within the flow cell, the membrane comprising an elastomeric material and columns of conductive material, the columns of conductive material defining conductive pathways;

urging with a clamping member the flow cell and the electrical circuitry in proximity to one another with the membrane disposed therebetween, whereby the conductive pathways are established between electrical contacts associated with the flow cell and corresponding electrical contacts associated with the electrical circuitry and whereby the membrane forms a barrier to prevent liquid intrusion into the electrical circuitry; and

transmitting electrical signals from the flow cell through the membrane to the electrical circuitry.

9. The method of claim 8, wherein the membrane is positioned between the flow cell and the electrical circuitry such that the flow cell and the electrical circuitry are substantially prevented from direct contact with each other.

10. The method of claim 8, wherein the flow cell is urged in proximity to the electrical circuitry with the membrane disposed therebetween by a clamping force substantially preventing fluid from contacting the electrical circuitry and establishing the conductive pathways between the flow cell and the electrical circuitry.

11. The method of claim 8, wherein a conformable characteristic of the membrane accommodates surface perturbations present on the flow cell while establishing the conductive pathways between the electrical contacts of the flow cell and the corresponding electrical contacts associated with the electrical circuitry.

12. The method of claim 8, wherein a conformable characteristic of the membrane accommodates at least partial deformation of the flow cell while establishing the conductive pathways between the electrical contacts associated with the flow cell and the corresponding electrical contacts associated with the electrical circuitry.

13. The method of claim 8, wherein the electrical contacts associated with the flow cell and the corresponding electrical contacts associated with the electrical circuitry comprise a material resistant to galvanic corrosion.

14. The method of claim 8, wherein the electrical components of the flow cell comprise one or more chemical field effect transistor (chemFET) sensors configured to detect the at least one analyte in the fluid.

15. An electrical connector for a flow cell, comprising:

a conductive membrane forming a fluidic barrier between the flow cell and an electrical circuitry to prevent fluid intrusion to the electrical circuitry, the conductive membrane establishing conductive pathways through the conductive membrane, the conductive pathways electrically connecting one or more contacts associated with the flow cell and one or more corresponding contacts associated with the electrical circuitry, the conductive membrane comprising an elastomeric material and columns of conductive material, the columns of conductive material defining the conductive pathways, wherein the one or more corresponding contacts associated with the electrical circuitry and the one or more contacts associated with the flow cell are positioned on opposing sides of the membrane, the flow cell having one or more fluid transfer ports, and the flow cell further being associated with at least one electrical component for detecting at least one analyte within the flow cell, and

a clamping member configured to urge the flow cell in proximity to the electrical circuitry with the conductive membrane disposed therebetween establishing the conductive pathways between the flow cell and the electrical circuitry while preventing fluid from contacting the electrical circuitry.

16. The electrical connector of claim 15, wherein the flow cell comprises a chemical field effect transistor (chemFET) sensor configured to detect the at least one analyte in fluid contained in the flow cell and configured to generate signals in response to the at least one analyte that are passed to the electrical circuitry through the electrical connector.

17. The electrical connector of claim 15, wherein the conductive membrane is provided with a conformable characteristic that accommodates surface perturbations present on the flow cell while establishing the conductive pathways between the one or more contacts associated with the flow cell and the one or more corresponding contacts associated with the electrical circuitry.

18. The electrical connector of claim 15, wherein the one or more contacts associated with the flow cell and the one or more corresponding contacts associated with the electrical circuitry comprise a material resistant to galvanic corrosion.

19. The electrical connector of claim 15, wherein the conformable electrically conductive membrane is to isolate the conductive pathways from liquid intrusion.