Method and apparatus for extraction of a sample from a sample source

• US 8,398,583 B2
• Filed: 09/10/2010
• Issued: 03/19/2013
• Est. Priority Date: 07/09/2008
• Status: Expired due to Fees

• Current Assignee: Massachusetts Institute of Technology
• Original Assignee: Massachusetts Institute of Technology
• Inventors: Hunter, Ian W., Taberner, Andrew J., Hogan, N. Catherine
• Primary Examiner(s): DOUGHERTY, SEAN PATRICK
• Application Number:
  US12/879,787
• Publication Number:
  US 20110082388A1
• Time in Patent Office: 921 Days
• Field of Search: 600/562, 600/573, 600/68, 600/73, 604/33
• US Class Current: 604/68
• CPC Class Codes: A61B 10/0045 Devices for taking samples of body liquids devices for taking blood samples A61B5/15
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 10/0283 with vacuum aspiration, e.g. caused by retractable plunger or by connected syringe A61B10/025, A61B10/0266 take precedence
• CPC Class Codes: A61B 2010/008 Interstitial fluid
• CPC Class Codes: A61M 2005/3128 Incorporating one-way valves, e.g. pressure-relief or non-return valves
• CPC Class Codes: A61M 2205/8287 operated by an external magnetic or electromagnetic field
• CPC Class Codes: A61M 5/19 having more than one chamber , e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly surgical glue applicators A61B17/00491
• CPC Class Codes: A61M 5/30 Syringes for injection by jet action, without needle, e.g. for use with replaceable ampoules or carpules

Abstract

The present invention relate to a method and corresponding apparatus for extraction of a sample from a sample source. A fluid is injected into the sample source and the sample source is vibrated. A sample is withdrawn from the vibrated sample source and the sample source is evaluated by measuring one or more identifying parameters in the withdrawn sample.

Claims

1. An apparatus for extraction of a sample from a sample source, the apparatus comprising:

a bi-directional needle-free injector that injects a fluid into the sample source, vibrates the sample source to facilitate withdrawal of the sample from the sample source and withdraws the sample from the sample source; and

a sample evaluator that evaluates the sample source as a function of measuring one or more identifying parameters in the withdrawn sample.

2. The apparatus of claim 1 wherein the injector is configured to inject into, vibrate, and withdraw from tissue of a biological body as the sample source.

3. The apparatus of claim 1 wherein the injected fluid is physiological saline.

4. The apparatus of claim 1 wherein the injector is configured to withdraw an extracellular fluid as the sample.

5. The apparatus of claim 1 wherein the one or more identifying parameters include metabolic or proteomic parameters.

6. A method for extraction of a sample from a sample source using the apparatus of claim 1, the method comprising:

injecting a fluid into the sample source;

vibrating the sample source and withdrawing a sample from the sample source; and

evaluating the sample source as a function of measuring one or more identifying parameters in the withdrawn sample.

7. The method of claim 1 wherein the sample source includes tissue of a biological body.

8. The method of claim 1 wherein the injected fluid is physiological saline.

9. The method of claim 1 wherein the withdrawn sample is an extracellular fluid.

10. The method of claim 1 wherein the one or more identifying parameters include metabolic or proteomic parameters.