Stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient

• US 8,398,704 B2
• Filed: 02/25/2010
• Issued: 03/19/2013
• Est. Priority Date: 02/26/2008
• Status: Active Grant

• Current Assignee: JenaValve Technology, Inc.
• Original Assignee: JenaValve Technology, Inc.
• Inventors: Straubinger, Helmut, Jung, Johannes, Girard, Michael J., Mayer, Arnulf
• Primary Examiner(s): Sweet, Thomas J
• Assistant Examiner(s): STEWART, JASON-DENNIS NEILKEN
• Application Number:
  US12/713,058
• Publication Number:
  US 20100191320A1
• Time in Patent Office: 1,118 Days
• Field of Search: 623/1.13, 623/1.15, 623/1.24, 623 21- 219
• US Class Current: 623/1.15
• CPC Class Codes: A61F 2/2418 Scaffolds therefor, e.g. support stents
• CPC Class Codes: A61F 2220/0016 with sharp anchoring protrusions, e.g. barbs, pins, spikes
• CPC Class Codes: A61F 2220/0058 soldered or brazed or welded
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/0023 triangular
• CPC Class Codes: A61F 2230/0054 V-shaped

Abstract

The present invention relates to a stent for the positioning and anchoring of a valvular prosthesis in an implantation site in the heart of a patient. Specifically, the present invention relates to an expandable stent for an endoprosthesis used in the treatment of a narrowing of a cardiac valve and/or a cardiac valve insufficiency. So as to ensure that no longitudinal displacement of a valvular prosthesis fastened to a stent will occur relative the stent in the implanted state of the stent, even given the peristaltic motion of the heart, the stent according to the invention comprises at least one fastening portion via which the valvular prosthesis is connectable to the stent. The stent further comprises positioning arches and retaining arches, whereby at least one positioning arch is connected to at least one retaining arch.

Claims

1. An expandable stent for implantation in a patient, comprising:

a plurality of positioning arches, each having an apex oriented toward a proximal end of the stent and configured to be positioned radially outward with respect to a plurality of leaflets of a native valve;

a plurality of retaining arches, each having an apex oriented toward the proximal end of the stent and configured to be positioned radially inward with respect to the plurality of leaflets of the native valve;

a plurality of sets of closed cells, each set disposed circumferentially between an adjacent pair of the plurality of retaining arches; and

an annular collar attached to the respective apices of the plurality of retaining arches at a distal end of the annular collar.

2. The expandable stent of claim 1, wherein each set of closed cells includes a plurality of dissimilarly shaped closed cells.

3. The expandable stent of claim 1, wherein each set of closed cells defines a pattern of closed cells, and wherein each pattern is substantially the same shape.

4. The expandable stent of claim 1, wherein the annular collar defines a lattice structure about a circumference of the stent.

5. The expandable stent of claim 4, further including a plurality of eyelets extending from a proximal end of the annular collar, opposite the distal end of the annular collar.

6. The expandable stent of claim 1, wherein the annular collar includes only a single row of closed cells.

7. The expandable stent of claim 1, further including a plurality of third arches, each having an apex oriented toward a distal end of the stent, opposite the proximal end of the stent, and each being substantially circumferentially aligned with a respective one of the plurality of positioning arches.

8. The expandable stent of claim 7, wherein:

the plurality of positioning arches includes three and only three positioning arches;

the plurality of retaining arches includes three and only three retaining arches;

the plurality of third arches includes three and only three retaining arches; and

the plurality of sets of closed cells includes three and only three sets of closed cells.

9. The expandable stent of claim 7, wherein:

each of the plurality of positioning arches includes a pair of arms connected together at first ends thereof to form the apex of a respective positioning arch; and

each of the third arches is positioned circumferentially between the arms of a respective positioning arch.

10. The expandable stent of claim 1, wherein:

the plurality of positioning arches includes three and only three positioning arches;

the plurality of retaining arches includes three and only three retaining arches; and

the plurality of sets of closed cells includes three only three sets of closed cells.

11. The expandable stent of claim 1, wherein a prosthetic valve is attached to the stent via sutures to each of the retaining arches and each set of closed cells.

12. The expandable stent of claim 11, wherein the prosthetic valve is made from one of pericardium tissue, tissue grown from cell cultures, or a biological valve.

13. The expandable stent of claim 1, further including a plurality of notches formed in a side of each of the plurality of retaining arches.

14. An expandable stent for implantation in a patient, comprising:

three and only three positioning arches, each having an apex oriented toward a proximal end of the stent and configured to be positioned radially outward with respect to a plurality of leaflets of a native valve;

three and only three retaining arches, each having an apex oriented toward the proximal end of the stent and configured to be positioned radially inward with respect to the plurality of leaflets;

three and only three sets of closed cells, each set disposed circumferentially between an adjacent pair of the plurality of retaining arches; and

an annular collar attached to the respective apices of the three retaining arches, the annular collar defining a lattice structure about a circumference of the stent and having only a single row of closed cells.

15. The expandable stent of claim 14, wherein each set of closed cells includes a plurality of dissimilarly shaped closed cells.

16. The expandable stent of claim 14, wherein each set of closed cells defines a pattern of closed cells, and wherein each pattern is substantially the same shape.

17. The expandable stent of claim 14, further including a three and only three third arches, each having an apex oriented toward a distal end of the stent, opposite the proximal end of the stent, and each being substantially circumferentially aligned with a respective one of the three positioning arches.

18. The expandable stent of claim 14, wherein a prosthetic valve is attached to the stent via sutures to each of the three retaining arches and each of the three sets of closed cells.

19. The expandable stent of claim 14, wherein a prosthetic valve is attached to the stent via sutures to each of the three retaining arches, each of the three sets of closed cells, and the annular collar.

20. The expandable stent of claim 19, wherein the prosthetic valve is made from one of pericardium tissue, tissue grown from cell cultures, or a biological valve.

21. The expandable stent of claim 14, further including a plurality of notches formed in a side of each of the plurality of retaining arches.

22. The expandable stent of claim 14, wherein the annular collar is attached to the respective apices of the three retaining arches at a distal end of the annular collar, the expandable stent further including a plurality of eyelets extending from a proximal end of the annular collar, opposite the distal end of the annular collar.

23. The expandable stent of claim 14, wherein each of the three sets of closed cells includes a closed cell having a boundary formed at least partially by an arm of a retaining arch.

24. The expandable stent of claim 14, wherein each of the three sets of closed cells includes a closed cell having a boundary formed at least partially by a portion of the annular collar.

25. An expandable stent for implantation in a patient, comprising:

a plurality of positioning arches, each having an apex oriented toward a proximal end of the stent and configured to be positioned radially outward with respect to a plurality of leaflets of a native valve;

a plurality of retaining arches, each having an apex oriented toward the proximal end of the stent and configured to be positioned radially inward with respect to the plurality of leaflets of the native valve; and

a plurality of sets of closed cells, each set disposed circumferentially between an adjacent pair of the plurality of retaining arches; and

a plurality of third arches, each having an apex oriented toward a distal end of the stent, opposite the proximal end of the stent, and each being substantially circumferentially aligned with a respective one of the plurality of positioning arches.

26. The expandable stent of claim 25, wherein:

the plurality of positioning arches includes three and only three positioning arches;

the plurality of retaining arches includes three and only three retaining arches;

the plurality of third arches includes three and only three retaining arches; and

the plurality of sets of closed cells includes three and only three sets of closed cells.

27. The expandable stent of claim 25, wherein:

each of the plurality of positioning arches includes a pair of arms connected together at first ends thereof to form the apex of a respective positioning arch; and

each of the third arches is positioned circumferentially between the arms of a respective positioning arch.

28. The expandable stent of claim 25, wherein a prosthetic valve is attached to the stent via sutures to each of the retaining arches and each set of closed cells.

29. The expandable stent of claim 25, wherein the prosthetic valve is made from one of pericardium tissue, tissue grown from cell cultures, or a biological valve.

30. The expandable stent of claim 25, further including a plurality of notches formed in a side of each of the plurality of retaining arches.

31. The expandable stent of claim 25, further including an annular collar attached to the respective apices of the plurality of retaining arches, the annular collar defining a lattice structure about a circumference of the stent.

32. The expandable stent of claim 31, wherein the lattice structure of the annular collar includes only a single row of closed cells.

33. The expandable stent of claim 31, wherein the annular collar is attached to the respective apices of the plurality of retaining arches at a distal end of the annular collar.

34. The expandable stent of claim 33, further including a plurality of eyelets extending from a proximal end of the annular collar, opposite the distal end of the annular collar.

35. An expandable stent for implantation in a patient, comprising:

a plurality of positioning arches, each having an apex oriented toward a proximal end of the stent and configured to be positioned radially outward with respect to a plurality of leaflets of a native valve;

a plurality of retaining arches, each having an apex oriented toward the proximal end of the stent and configured to be positioned radially inward with respect to the plurality of leaflets of the native valve; and

a plurality of sets of closed cells, each set disposed circumferentially between an adjacent pair of the plurality of retaining arches; and

an annular collar attached to the respective apices of the plurality of retaining arches at a distal end of the annular collar, the annular collar defining a lattice structure about a circumference of the stent, wherein the annular collar includes a single row of closed cells.

36. An expandable stent for implantation in a patient, comprising:

a plurality of positioning arches, each having an apex oriented toward a proxima end of the stent and configured to be positioned radially outward with respect to a plurality of leaflets of a native valve;

a plurality of retaining arches, each having an apex oriented toward the proxima end of the stent and configured to be positioned radially inward with respect to the plurality of leaflets of the native valve; and

a plurality of sets of closed cells, each set disposed circumferentially between an adjacent pair of the plurality of retaining arches;

wherein a prosthetic valve is attached to the stent via sutures to each of the retaining arches and each set of closed cells.

37. The expandable stent of claim 36, wherein the prosthetic valve is made from one of pericardium tissue, tissue grown from cell cultures, or a biological valve.