Degradable therapeutic delivery device
First Claim
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1. A vaginal insert comprising:
- an insert member having a shape configured to be inserted into a vagina, the insert member being constructed from a biodegradable elastic polymer, the polymer comprising a crosslinked reaction product of a polyol and a polyacid, wherein the polyol is at least difunctional and the polyacid is at least trifunctional and the polyacid is 1,2,4-butanetricarboxylic acid or 1,3,5-pentanetricarboxylic acid, the insert member further comprising a therapeutic or medicinal agent chemically bonded to the elastic polymer.
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Abstract
A biodegradable biodelivery device is disclosed. The biodelivery device is formed from a polymer comprising the reaction product of a polyol and a polyacid. When exposed to water, the polymer degrades through hydrolysis. Of particular advantage, the polymer can be formed so as to be elastic and flexible. In one embodiment, the polymer is formed into a vaginal insert. As the polymer degrades, the polymer releases acid to a vaginal environment for decreasing the pH of the environment.
30 Citations
14 Claims
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1. A vaginal insert comprising:
an insert member having a shape configured to be inserted into a vagina, the insert member being constructed from a biodegradable elastic polymer, the polymer comprising a crosslinked reaction product of a polyol and a polyacid, wherein the polyol is at least difunctional and the polyacid is at least trifunctional and the polyacid is 1,2,4-butanetricarboxylic acid or 1,3,5-pentanetricarboxylic acid, the insert member further comprising a therapeutic or medicinal agent chemically bonded to the elastic polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
Specification