Polyamine modified particles
First Claim
1. A particle composition comprising:
- a poly(lactide-coglycolide) (PLGA) microparticle or nanoparticle comprising;
a plurality of PLGA polymers covalently surface functionalized by a plurality of polyethyleneimine (PEI) moieties in a graft copolymer.
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Accused Products
Abstract
A particle composition comprising a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, and a combinatorial delivery polymer comprising a plurality of particles that comprises a graft copolymer of formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer, a plurality of nucleic acids electrostatically loaded onto the particles, a plurality of chemokine molecules, and a biodegradable polymer network, in which the loaded particles and chemokine molecules may be entrapped, are disclosed. Also disclosed is a method for treating a subject comprising administering a therapeutically effective dose of a pharmaceutical composition, the pharmaceutical composition comprising a particle composition that comprises a graft copolymer formed from a biocompatible polymer and a plurality of polyamine moieties, wherein the polyamine moieties are bound to the biocompatible polymer.
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Citations
28 Claims
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1. A particle composition comprising:
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a poly(lactide-coglycolide) (PLGA) microparticle or nanoparticle comprising; a plurality of PLGA polymers covalently surface functionalized by a plurality of polyethyleneimine (PEI) moieties in a graft copolymer. - View Dependent Claims (2, 3, 4, 5, 6, 16, 26)
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7. A combinatorial delivery polymer comprising:
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a poly(lactide-coglycolide) (PLGA) microparticle or nanoparticle comprising a plurality of PLGA polymers covalently surface functionalized by a plurality of polyethyleneimine (PEI) moieties in a graft copolymer; and a plurality of nucleic acids electrostatically bonded to the PEI moieties in the particles. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 17, 27)
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18. A particle composition comprising:
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a poly(lactide-coglycolide) (PLGA) microparticle or nanoparticle comprising; a plurality of PLGA polymers covalently bonded to the PEI moieties in a graft copolymer wherein the microparticle or nanoparticle is operable to electrostatically bind a nucleic acid via the PEI moieties. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 28)
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Specification