Use of the extracellular marker DNER for identification and selection of specific pancreatic cells
First Claim
1. A method of identifying cells that have the potential to differentiate into pancreatic cells, the method comprising contacting a cell population comprising cells selected from the group consisting of endocrine pre-progenitor cells, endocrine progenitor cells, early endocrine cells, and/or fully differentiated endocrine cells with a DNER binding reagent wherein the cells that bind to the DNER reagent (DNER-positive cells) have the potential to differentiate into pancreatic cells.
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Abstract
The invention relates to a method of identifying and obtaining cells that have the potential to differentiate into pancreatic cells, having the step of contacting a cell population containing endocrine pre-progenitor cells, endocrine progenitor cells, early endocrine cells, and/or fully differentiated endocrine cells with a DNER binding agent; as well as isolating and/or expanding cells obtained by the method and compositions thereof.
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12 Claims
- 1. A method of identifying cells that have the potential to differentiate into pancreatic cells, the method comprising contacting a cell population comprising cells selected from the group consisting of endocrine pre-progenitor cells, endocrine progenitor cells, early endocrine cells, and/or fully differentiated endocrine cells with a DNER binding reagent wherein the cells that bind to the DNER reagent (DNER-positive cells) have the potential to differentiate into pancreatic cells.
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7. A method of quantifying DNER positive pancreatic cells by a) contacting the cells with a DNER binding reagent;
- and b) determining the quantity of cells that bind the DNER reagent (DNER positive cells).
Specification