Contact lenses

• US 8,399,538 B2
• Filed: 09/23/2010
• Issued: 03/19/2013
• Est. Priority Date: 03/02/1998
• Status: Expired due to Term

• Current Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Original Assignee: Johnson & Johnson Vision Care Incorporated (Johnson & Johnson)
• Inventors: Steffen, Robert B., Turner, David C., Vanderlaan, Douglas
• Primary Examiner(s): CAIN, EDWARD J
• Application Number:
  US12/888,474
• Publication Number:
  US 20110015352A1
• Time in Patent Office: 908 Days
• Field of Search: 523/106, 523/107, 523/108
• US Class Current: 523/107
• CPC Class Codes: C08F 230/085 the monomer being a polymerisable silane, e.g. (meth)acryloyloxy trialkoxy silanes or vinyl trialkoxysilanes
• CPC Class Codes: C08F 290/068 Polysiloxanes
• CPC Class Codes: C08L 43/04 Homopolymers or copolymers of monomers containing silicon
• CPC Class Codes: C08L 51/085 on to polysiloxanes
• CPC Class Codes: C08L 83/04 Polysiloxanes
• CPC Class Codes: C09D 133/02 Homopolymers or copolymers of acids; Metal or ammonium salts thereof
• CPC Class Codes: C09D 133/10 Homopolymers or copolymers of methacrylic acid esters
• CPC Class Codes: C09D 133/26 Homopolymers or copolymers of acrylamide or methacrylamide
• CPC Class Codes: G02B 1/043 Contact lenses
• CPC Class Codes: G02C 7/049 Contact lenses having special fitting or structural features achieved by special materials or material structures

Abstract

The invention provides silicone hydrogel contact lenses that exhibit reduced back surface debris and reduced incidence of superior epithelial arcurate lesions.

Claims

1. A silicone-containing contact lens comprising a center stiffness of about 1 psi·

mm² or less, wherein the lens exhibits an advancing contact angle of less than about 80 degrees and said contact lens is formed from a polymer reaction mixture comprising at least one monomethacryloxypropyl terminated polydimethylsiloxane of the formula;

2. The contact lens of claim 1 wherein b is an integer from 8 to 10, R₅₈ is a methacrylate moiety;

each R₅₉ is methyl; and

R₆₀ is selected from the group consisting of C_1-10 aliphatic or aromatic group which may include hetero atoms.

3. The contact lens of claim 1 wherein R₆₀ is selected from the group consisting of C_3-8 alkyl groups.

4. The contact lens of claim 1, wherein said lens further comprises an internal wetting agent selected from the group consisting of polyamides, polylactams, polyimides, polylactones, and combinations thereof.

5. The contact lens of claim 1, wherein the polymerizable mixture further comprises poly(N-vinyl pyrrolidinone).

6. The contact lens of claim 1, further comprising a coating selected from the group consisting of poly(acrylic acid), poly(methacrylic acid), poly(maleic acid), poly(itaconic acid), poly(acrylamide), poly(dimethacrylamide), block or random copolymers of (meth)acrylic acid, acrylic acid, maleic acid, itaconic acid with any reactive vinyl monomer, carboxymethylated polymers, such as carboxymethylcellulose, dextran, polyvinyl alcohol, polyethylene oxide, poly(2-hydroxy ethyl methacrylate), polysulfonates, polysulfates, polylactam, polyglycolic acid, polyamines, and mixtures thereof.

7. The contact lens of claim 1, further comprising a coating selected from the group consisting of poly(acrylic acid), poly(methacrylic acid), poly(maleic acid), poly(itaconic acid), poly(acrylamide), poly(dimethacrylamide), block or random copolymers of (meth)acrylic acid, acrylic acid, maleic acid, itaconic acid with any reactive vinyl monomer, carboxymethylated polymers, such as carboxymethylcellulose, dextran, polyvinyl alcohol, polyethylene oxide, poly(2-hydroxyethyle methacrylate), polysulfonates, polysulfates, polylactam, polyglycolic acid, polyamines, and mixtures thereof.

8. The contact lens of claim 7, wherein the coating is poly(acrylic acid), poly(acrylamide), or poly(2-hydroxyethyl methacrylate).

9. The contact lens of claim 1, wherein the lens provided comprises a center stiffness less than about 0.5 psi·

mm².

10. The contact lens of claim 1 wherein said polymer reaction mixture further comprises at least one hydrophilic monomer.

11. The contact lens of claim 10 wherein said hydrophilic monomer is selected from the group consisting of 2-hydroxyethyl methacrylate, 2-hydroxyethyl acrylate, N,N-dimethylacrylamide, N-vinylpyrrolidone, 2-vinyl-4,4′

-diethyl-2-oxazolin-5-one, methacrylic acid and 2-hydroxyethyl methacrylamide.

12. The contact lens of claim 1 wherein said lens is formed from a polymer reaction mixture comprising at least one linear, branched or star macromer.

13. The contact lens of claim 1, or 12 wherein said lens is formed via direct molding.

14. The contact lens of claim 13 wherein said lens is treated with water, a solvent or both after direct molding.

15. The contact lens of claim 1, or 12 wherein said reaction mixture further comprises at least one diluent.

16. The contact lens of any of claim 1, or 12 wherein said lens is plasma coated.