Devices and methods for treatment of heart failure and associated conditions

• US 8,401,652 B2
• Filed: 01/27/2012
• Issued: 03/19/2013
• Est. Priority Date: 06/16/2008
• Status: Active Grant

• Current Assignee: CVRx, Inc.
• Original Assignee: CVRx, Inc.
• Inventors: Georgakopoulos, Dimitrios, Lovett, Eric Grant
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): Stice, Paula J
• Application Number:
  US13/360,339
• Publication Number:
  US 20120123506A1
• Time in Patent Office: 417 Days
• Field of Search: 607/44, 607/2
• US Class Current: 607/44
• CPC Class Codes: A61N 1/36139 with automatic adjustment
• CPC Class Codes: A61N 1/372 Arrangements in connection with the implantation of stimulators
• CPC Class Codes: F01K 25/005 the working fluid being steam, created by combustion of hydrogen with oxygen
• CPC Class Codes: F02C 3/22 the fuel or oxidant being gaseous at standard temperature and pressure F02C3/28 takes precedence
• CPC Class Codes: F02C 3/30 Adding water, steam or other fluids for influencing combustion, e.g. to obtain cleaner exhaust gases F02C7/141, F02C7/30, F01D21/00, F01K21/04, F23D11/10 take precedence
• CPC Class Codes: F05D 2220/31 in steam turbines

Abstract

Devices and methods of use are described for detecting and treating an undesirable level of fluid in a pulmonary circulation of a patient. An exemplary system may include an implantable baroreflex activation device including an electrode configured to be implanted proximate a baroreptor within a patient, an implantable sensor configured to provide an indication of a fluid level within the patient, and a control system coupled to the baroreflex activation device and the sensor. The control system may be programmed to automatically detect a level of a fluid in a pulmonary circulation of the patient with the sensor and upon detecting an undesirable level of the fluid in the pulmonary circulation, delivering a therapy via the electrode of the baroreflex activation device to reduce the level of fluid in the pulmonary circulation.

Claims

1. A method, comprising:

implanting a sensor within a patient;

implanting a baroreflex therapy system within the patient, the baroreflex therapy system including an electrode;

automatically detecting with the sensor an undesirable level of fluid in a pulmonary circulation of the patient; and

automatically delivering a therapy with the baroreflex therapy system via the electrode in response to the detecting an undesirable level of fluid in the pulmonary circulation to reduce the level of fluid in the pulmonary circulation.

2. The method of claim 1, further comprising:

upon detecting with the sensor an acceptable level of fluid in the pulmonary circulation, automatically delivering a second therapy with the baroreflex therapy system to maintain the acceptable level of fluid in the pulmonary circulation.

3. The method of claim 2, wherein automatically delivering the second therapy comprises cessation of therapy.

4. The method of claim 1, further comprising:

implanting a second sensor within the patient;

monitoring a level of fluid within a splanchnic circulation of the patient with the second sensor; and

modulating the baroreflex therapy based at least in part on the level of fluid sensed within the splanchnic circulation.

5. A method, comprising:

causing a baroreflex therapy system to be manufactured and made available to a user;

causing a sensor to be manufactured and made available to the user; and

providing instructions recorded on a tangible medium to the user, the instructions comprising;

implanting the baroreflex activation device within a patient;

implanting the sensor within the patient;

causing the sensor to detect an undesirable level of fluid in a pulmonary circulation of the patient; and

causing the baroreflex therapy system to deliver a therapy in response to the detecting an undesirable level of fluid in the pulmonary circulation, the therapy to reduce the level of fluid in the pulmonary circulation.

6. The method of claim 5, wherein the baroreflex therapy system includes an electrode, wherein the instructions for implanting the baroreflex therapy system within the patient further comprises implanting the baroreflex therapy system within the patient such that the electrode is proximate a baroreceptor, and wherein the instructions for causing the baroreflex therapy system to deliver a therapy further comprises causing the baroreflex therapy system to deliver a therapy to stimulate the baroreceptor via the electrode.

7. The method of claim 5, wherein the instructions further comprise:

implanting a second sensor within the patient;

monitoring a level of fluid within a splanchnic circulation of the patient with the second sensor; and

causing the baroreflex therapy system to modulate the therapy based at least in part on the level of fluid sensed within the splanchnic circulation.

8. A therapy system, comprising:

an implantable baroreflex activation device including an electrode configured to be implanted proximate a baroreptor within a patient;

an implantable sensor configured to provide an indication of a fluid level within the patient;

a control system coupled to the baroreflex activation device and the sensor, the control system programmed to automatically;

detect a level of a fluid in a pulmonary circulation of the patient with the sensor; and

upon detecting an undesirable level of the fluid in the pulmonary circulation, delivering a therapy via the electrode of the baroreflex activation device to reduce the level of fluid in the pulmonary circulation.

9. The system of claim 8, further comprising a second sensor operably coupled to the control system, wherein the first sensor and the second sensor are configured to provide transthoracic impedance.

10. The system of claim 8, further comprising a second sensor operably coupled to the control system, the second sensor configured to provide an indication of a fluid level within the splanchnic circulation of the patient to the control system, and wherein the control system is programmed to automatically modulate the therapy based at least in part on the indication of a fluid level within the splanchnic circulation of the patient.

11. The system of claim 10, further comprising a second sensor operably coupled to the control system, the second sensor configured to provide an indication of a posture of the patient to the control system, and wherein the control system is programmed to automatically modulate the therapy based at least in part on the indication of the posture of the patient.

12. The system of claim 8, further comprising a second sensor operably coupled to the control system, wherein the first sensor and the second sensor are implanted in contact with a blood vessel, and wherein the control system is configure to determine an impedance of the blood vessel using the first sensor and the second sensor.