Multi-opening reservoir devices for controlled release or exposure of reservoir contents

• US 8,403,915 B2
• Filed: 10/19/2009
• Issued: 03/26/2013
• Est. Priority Date: 09/01/2004
• Status: Active Grant

• Current Assignee: DARE MB Incorporated
• Original Assignee: MicroCHIPS Inc.
• Inventors: Santini, John T. Jr., Sbiaa, Zouhair, Coppeta, Jonathan R., Uhland, Scott A., Sheppard, Norman F. Jr.
• Primary Examiner(s): SHUMATE, VICTORIA PEARL
• Application Number:
  US12/581,558
• Publication Number:
  US 20100042075A1
• Time in Patent Office: 1,254 Days
• Field of Search: 604/244, 604/246, 604/256, 604/890.1
• US Class Current: 604/891.1
• CPC Class Codes: A61K 9/0009 involving or responsive to electricity, magnetism or acoustic waves; Galenical aspects of sonophoresis, iontophoresis, electroporation or electroosmosis microelectromechanical systems A61K9/0097
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0097 Micromachined devices; Microelectromechanical systems [MEMS]; Devices obtained by lithographic treatment of silicon; Devices comprising chips intradermal microneedle arrays A61K9/0021; MEMS in general B81B7/02
• CPC Class Codes: A61M 5/14 Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/05 for implantation or insertion into the body, e.g. heart electrode A61N1/06 takes precedence
• CPC Class Codes: B01L 2300/0627 Sensor or part of a sensor is integrated
• CPC Class Codes: B01L 2300/0819 Microarrays; Biochips
• CPC Class Codes: B01L 2400/0677 phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
• CPC Class Codes: B01L 3/50853 with covers or lids
• CPC Class Codes: Y10T 436/25 including sample preparation

Abstract

Devices, such as medical devices, are provided which include a body portion having at least one reservoir which has two or more openings, the two or more openings being defined in part by a reservoir cap support; reservoir contents, such as a drug formulation or sensor, disposed inside the reservoir; and a reservoir cap which closes off the two or more reservoir openings. The reservoir cap, which can be ruptured, controls release or exposure of the reservoir contents. In one embodiment, the device is an implantable medical device and provides for the controlled release of drug or exposure of a sensor.

Claims

1. A method of permitting the ingress or egress of a substance to or from a medical device implanted in a patient, comprising:

disintegrating a first reservoir cap portion covering a first opening of a containment reservoir defined by a substrate of the medical device; and

disintegrating a second reservoir cap portion covering a second opening of the containment reservoir,

wherein the first and second reservoir cap portions are positioned on an outer surface of the medical device.

2. The method of claim 1, wherein the first reservoir cap portion is a first discrete reservoir cap and the second reservoir cap portion is a second discrete reservoir cap.

3. The method of claim 1, wherein the disintegration of the first and second reservoir cap portions occurs simultaneously.

4. The method of claim 1, wherein the disintegration of the first and second reservoir cap portions occurs serially.

5. The method of claim 1, wherein the containment reservoir comprises a drug or a sensor.

6. The method of claim 1, wherein the containment reservoir comprises a drug and the drug is released from the first and second openings.

7. The method of claim 1, wherein the containment reservoir comprises a sensor.

8. The method of claim 1, wherein at least one reservoir cap support spans from one side to an opposed side of the containment reservoir between the first and second openings.

9. The method of claim 1, further comprising activating a control means to selectively disintegrate the first and second reservoir cap portions.

10. The method of claim 1, wherein the first and second reservoir cap portions are positioned on the same outer surface of the medical device.

11. The method of claim 1, wherein the containment reservoir is hermetically sealed.

12. A method of permitting the ingress or egress of a substance to or from a containment cavity of a medical device implanted in a patient, comprising:

disintegrating a first cavity cap portion covering a first opening of the containment cavity; and

disintegrating a second cavity cap portion covering a second opening of the containment cavity;

wherein the first and second cavity cap portions are positioned on an outer surface of the medical device.

13. The method of claim 12, wherein the first cavity cap portion is a first discrete cavity cap and the second cavity cap portion is a second discrete cavity cap.

14. The method of claim 12, wherein the disintegration of the first and second cavity cap portions occurs simultaneously.

15. The method of claim 12, wherein the disintegration of the first and second cavity cap portions occurs serially.

16. The method of claim 12, wherein the containment cavity contains a drug and the drug is released from the first and second openings.

17. The method of claim 12, wherein the containment cavity contains a sensor.

18. The method of claim 12, wherein at least one cavity cap support spans from one side to an opposed side of the containment cavity between the first and second openings.

19. A method of controlled release or exposure of reservoir contents of a medical device, comprising:

implanting the medical device in a patient, wherein a substrate of the medical device defines a containment reservoir having a first opening and a second opening;

disintegrating a first reservoir cap portion covering the first opening to release or expose the reservoir contents; and

disintegrating a second reservoir cap portion covering the second opening to release or expose the reservoir contents.

20. The method of claim 19, wherein the reservoir contents comprise a drug or a sensor.