Device for regeneration of articular cartilage and other tissue
First Claim
1. A porous, multi-component device for repair of articular cartilage defects, comprising:
- a. a first region comprising a first component in the form of a microstructure presenting a porous intercommunicating network for cellular attachment, and a second component in the form of a fibrous macrostructure supporting the first component and;
b. a second region comprising a third component of porous polymer attached to the first and second components.
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Abstract
An implantable device for facilitating the healing of voids in bone, cartilage and soft tissue is disclosed. A preferred embodiment includes a cartilage region comprising a polyelectrolytic complex joined with a subchondral bone region. The cartilage region, of this embodiment, enhances the environment for chondrocytes to grow articular cartilage; while the subchondral bone region enhances the environment for cells which migrate into that region'"'"'s macrostructure and which differentiate into osteoblasts. A hydrophobic barrier exists between the regions, of this embodiment. In one embodiment, the polyelectrolytic complex transforms to hydrogel, following the implant procedure.
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Citations
14 Claims
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1. A porous, multi-component device for repair of articular cartilage defects, comprising:
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a. a first region comprising a first component in the form of a microstructure presenting a porous intercommunicating network for cellular attachment, and a second component in the form of a fibrous macrostructure supporting the first component and; b. a second region comprising a third component of porous polymer attached to the first and second components. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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Specification