Gated voltammetry
First Claim
1. In an electrochemical method for determining the concentration of an analyte in a sample, where the method includes applying an input signal to a sensor strip so the analyte undergoes a redox reaction to generate an electric current that is measured and correlated with the concentration of the analyte in the sample,the sensor strip including electrodes and reagents, where the reagents include an oxidoreductase and react with and transfer electrons from the analyte to the electrodes;
- the improvement comprising applying a gated voltammetric pulse sequence to the sample comprising at least two duty cycles, where each of the duty cycles includes an excitation and a relaxation, the relaxation is from 0.1 to 3 seconds, and the relaxation includes a current reduction to one-half or less of the current flow at the excitation maxima.
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Accused Products
Abstract
A sensor system, device, and methods for determining the concentration of an analyte in a sample is described. Gated voltammetric pulse sequences including multiple duty cycles of sequential excitations and relaxations may provide a shorter analysis time and/or improve the accuracy and/or precision of the analysis. The disclosed pulse sequences may reduce analysis errors arising from the hematocrit effect, variance in cap-gap volumes, non-steady-state conditions, mediator background, a single set of calibration constants, under-fill, and changes in the active ionizing agent content of the sensor strip.
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Citations
41 Claims
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1. In an electrochemical method for determining the concentration of an analyte in a sample, where the method includes applying an input signal to a sensor strip so the analyte undergoes a redox reaction to generate an electric current that is measured and correlated with the concentration of the analyte in the sample,
the sensor strip including electrodes and reagents, where the reagents include an oxidoreductase and react with and transfer electrons from the analyte to the electrodes; the improvement comprising applying a gated voltammetric pulse sequence to the sample comprising at least two duty cycles, where each of the duty cycles includes an excitation and a relaxation, the relaxation is from 0.1 to 3 seconds, and the relaxation includes a current reduction to one-half or less of the current flow at the excitation maxima. - View Dependent Claims (2, 3, 4)
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5. A voltammetric method for determining the concentration of an analyte in a sample, comprising:
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applying a pulse sequence to the sample, the pulse sequence having at least two duty cycles, where each of the duty cycles includes an excitation and a relaxation, where the excitation includes a potential varied with time, and where the relaxation is from 0.1 to 3 seconds and includes a current reduction to at least one-half the current flow at the excitation maxima; measuring resulting currents from at least one of the excitations including the potential varied with time; and determining the concentration of the analyte in the sample from at least one of the resulting currents. - View Dependent Claims (6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41)
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Specification