Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
First Claim
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1. A pharmaceutical formulation for pulmonary administration, comprising a plurality of particulates having a mass median diameter less than 20 μ
- m, wherein each particulate comprises;
(a) a lipid matrix; and
(b) at least one particle of an active agent in the lipid matrix, said active agent having an aqueous solubility of less than 1.0 mg/ml, wherein at least 90% of the active agent particles in the formulation have a geometric diameter less than 3 μ
m.
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Abstract
Formulations are provided for pulmonary administration of an antifungal agent to a patient. Methods of using the formulations in the treatment of antifungal infections are also provided, including treatment of pulmonary aspergillosis with amphotericin B-containing formulations. Methods of manufacturing the formulations to achieve optimum properties are provided as well.
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Citations
21 Claims
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1. A pharmaceutical formulation for pulmonary administration, comprising a plurality of particulates having a mass median diameter less than 20 μ
- m, wherein each particulate comprises;
(a) a lipid matrix; and
(b) at least one particle of an active agent in the lipid matrix, said active agent having an aqueous solubility of less than 1.0 mg/ml, wherein at least 90% of the active agent particles in the formulation have a geometric diameter less than 3 μ
m. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
- m, wherein each particulate comprises;
Specification