Sustained release implantable eye device

• US 8,404,269 B2
• Filed: 04/09/2004
• Issued: 03/26/2013
• Est. Priority Date: 04/11/2003
• Status: Expired due to Fees

• Current Assignee: Eric M. Dobrusin, Michael Snyder
• Original Assignee: Eric M. Dobrusin, Michael Snyder
• Inventors: Snyder, Michael, Dobrusin, Eric M.
• Primary Examiner(s): GHALI, ISIS A D
• Application Number:
  US10/821,745
• Publication Number:
  US 20050008673A1
• Time in Patent Office: 3,273 Days
• Field of Search: None
• US Class Current: 424/427
• CPC Class Codes: A61K 9/0024 Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue compositions for intravenous administration, normal injectable solutions or dispersions for, e.g. subcutaneous administration A61K9/0019; brain implants A61K9/0085; (coated) prostheses, catheters or stents A61L
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants

Abstract

A surgical device and method of making and using the same for implantation in a body of a mammal. One preferred device is prepared to include an elongated member. A region includes a pharmaceutical agent and a bioerodible material, a biodegradable material a bioavailable material or a mixture thereof.

Claims

1. An implantable device, comprising:

a) an implantable elongated hollow glaucoma drainage tube including a solid walled plastic lumen having a lumen section that extends into an eye and wraps generally circularly around cornea of said eye and includes a flow passage so that when the tube is implanted within the eye the tube has a first end located in a first portion of the eye and a second end located in a second portion of the eye and the flow passage spans between the first end and the second end; and

b) a sustained release medium including caprolactone and an antimicrobial within an interior of the lumen that is filled with the sustained release medium to define a head space passage that increases its degree of opening over time as matter is passed through the lumen;

wherein the lumen has a circular cross section fixed inner and outer dimension, defining a lumen diameter, the tube includes a plurality of openings of a fixed size and shape, through which the sustained release medium escapes, and the sustained release medium comprises a solid material.

2. The device of claim 1, wherein the lumen has open ends.

3. The device of claim 1, further comprising a radiological detectable marker that are monitored to correlate with a reduction in size of a wound site or a mass under consideration.

4. The device of claim 1, where the sustained release material is provided as layers.

5. The device of claim 2, further comprising a coating of the sustained release material on an exterior of the lumen and covering the openings, so that as a layer diminishes, the openings of the lumen become exposed and thereby provides gradually increasing volumes or areas through which the sustained release material that is filled within the lumen escapes from the lumen.

6. The device of claim 1, wherein the first end when implanted is located in an anterior chamber of the eye or in a pars plana portion of the eye.

7. The device of claim 6, wherein the lumen has open ends.

8. The device of claim 6, further comprising a radiological detectable marker that are monitored to correlate with a reduction in size of a wound site or a mass under consideration.

9. The device of claim 7, further comprising a radiological detectable marker that are monitored to correlate with a reduction in size of a wound site or a mass under consideration.

10. The device of claim 6, where the sustained release material is provided as layers.

11. The device of claim 7, where the sustained release material is provided as layers.

12. The device of claim 8, where the sustained release material is provided as layers.

13. The device of claim 6, further comprising a coating of the sustained release material on an exterior of the lumen and covering the openings, so that as a layer diminishes, the openings of the lumen become exposed and thereby provides gradually increasing volumes or areas through which the sustained release material that is filled within the lumen escapes from the lumen.

14. The device of claim 7, further comprising a coating of the sustained release material on an exterior of the lumen and covering the openings, so that as a layer diminishes, the openings of the lumen become exposed and thereby provides gradually increasing volumes or areas through which the sustained release material that is filled within the lumen escapes from the lumen.

15. The device of claim 9, further comprising a coating of the sustained release material on an exterior of the lumen and covering the openings, so that as a layer diminishes, the openings of the lumen become exposed and thereby provides gradually increasing volumes or areas through which the sustained release material that is filled within the lumen escapes from the lumen.

16. The device of claim 12, further comprising a coating of the sustained release material on an exterior of the lumen and covering the openings, so that as a layer diminishes, the openings of the lumen become exposed and thereby provides gradually increasing volumes or areas through which the sustained release material that is filled within the lumen escapes from the lumen.

17. The device of claim 4, wherein erosion of the layers is halted when a desired intraocular pressure is reached.

18. The device of claim 16, wherein erosion of the layers is halted when a desired intraocular pressure is reached.

19. The device of claim 1, wherein the device includes a focal surrounding element that can be altered to shrink and constrict the lumen.

20. The device of claim 16, wherein the device includes a focal surrounding element that can be altered to shrink and constrict the lumen.