Device and method for analyte sensing
First Claim
1. An analyte sensing device for sensing a concentration of analyte in a fluid, the analyte sensing device comprising:
- a polymeric matrix consisting of a plurality of porous beads or particles;
a semi-permeable housing that surrounds said polymeric matrix; and
an analyte sensing component disposed within the matrix and including a first radiation converting component that is capable of converting radiation of a first wavelength to at least one different wavelength at an efficiency of conversion that is dependent on the concentration of the analyte in the matrix;
wherein said housing is substantially permeable to said analyte and impermeable to said plurality of beads or particles.
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Abstract
In one aspect, the present invention is a system, a device and a method for sensing the concentration of an analyte in a fluid or matrix. The analyte may be glucose or any other chemical of interest. The fluid or matrix may be, for example, the fluid in a bioreactor, a food or agricultural product, any fluid or matrix in the body of an animal, or any other fluid or matrix whose concentration of an analyte is under investigation. In one embodiment, the analyte sensing device includes a housing having an interior space. Contained within the housing and in the interior space is one or more analyte sensing component(s). The analyte sensing component, in one embodiment, includes one or more radiation converting element(s), for example, converting chromophores. The radiation converting element(s) are capable of converting or modifying radiation of one or more wavelengths into radiation of one or more different wavelengths. The conversion efficiency of the radiation converting element(s) is at least partially dependent on the local concentration of an analyte within the analyte sensing component.
70 Citations
23 Claims
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1. An analyte sensing device for sensing a concentration of analyte in a fluid, the analyte sensing device comprising:
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a polymeric matrix consisting of a plurality of porous beads or particles; a semi-permeable housing that surrounds said polymeric matrix; and an analyte sensing component disposed within the matrix and including a first radiation converting component that is capable of converting radiation of a first wavelength to at least one different wavelength at an efficiency of conversion that is dependent on the concentration of the analyte in the matrix; wherein said housing is substantially permeable to said analyte and impermeable to said plurality of beads or particles. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An analyte sensing device for sensing a concentration of analyte in a fluid, the analyte sensing device comprising:
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a semi-permeable housing including a polymeric matrix consisting essentially of a plurality of beads or particles; and an analyte sensing component disposed within said polymeric matrix, said analyte sensing component comprising a plurality of radiation converting components capable of converting radiation of a first wavelength to at least one different wavelength, at least one of said radiation components converts radiation at an efficiency of conversion dependent on the concentration of the analyte in the matrix, and at least another of said radiation converting components is embedded in or attached to at least one of said plurality of beads or particles; wherein said housing is substantially permeable to said analyte and impermeable to said plurality of beads or particles. - View Dependent Claims (22, 23)
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Specification