Membrane bound stem cell factor therapy for ischemic heart

• US 8,404,653 B2
• Filed: 11/13/2006
• Issued: 03/26/2013
• Est. Priority Date: 11/14/2005
• Status: Active Grant

• Current Assignee: Enterprise Partners Venture Capital
• Original Assignee: Enterprise Partners Venture Capital
• Inventors: Zsebo, Krisztina M.
• Primary Examiner(s): Kelly, Robert M
• Application Number:
  US12/084,673
• Publication Number:
  US 20090304636A1
• Time in Patent Office: 2,325 Days
• Field of Search: None
• US Class Current: 514/44.R
• CPC Class Codes: A61K 48/005 characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
• CPC Class Codes: A61P 9/04 Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
• CPC Class Codes: A61P 9/08 Vasodilators for multiple indications
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Abstract

The present invention relates to the use of stem cell factor (SCF) for the treatment of ischemic injured tissue such as in cardiovascular disease. The method involves administration of a nucleic acid encoding SCF, wherein the nucleic acid is delivered to the site of the injury and is incorporated into cells which then express the SCF.

Claims

1. A method for treating a subject suffering from an ischemic injury of the heart resulting from myocardial infarction, consisting essentially of administering to the subject a nucleic acid encoding a membrane bound form of stem cell factor (SCF) wherein the nucleic acid is administered to the site of the injury where it is taken up by cells and SCF is expressed, wherein the expression of SCF results in repair of the ischemic injury.

2. The method of claim 1, wherein the SCF comprises amino acids 25-245 of SEQ ID NO:

1.

3. The method of claim 1, wherein the SCF is human SCF.

4. The method of claim 1, wherein the nucleic acid is a viral vector.

5. A method for treating a subject suffering from an ischemic injury of the heart resulting from myocardial infarction, comprising administering to the subject a nucleic acid encoding a membrane bound form of stem cell factor (SCF) wherein the nucleic acid is administered to the site of the injury where it is taken up by cells and SCF is expressed, wherein the expression of SCF results in repair of the ischemic injury, and wherein the subject is not administered granulocyte-colony stimulating factor (G-CSF).

6. The method of claim 5, wherein the SCF comprises amino acids 25-245 of SEQ ID NO:

1.

7. The method of claim 5, wherein the SCF is human SCF.

8. The method of claim 5, wherein the nucleic acid is a viral vector.