Spatially resolved oxymetry

• US 8,406,840 B2
• Filed: 09/07/2006
• Issued: 03/26/2013
• Est. Priority Date: 09/13/2005
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Nielsen, Tim, Koehler, Thomas
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): DANEGA, RENEE A
• Application Number:
  US12/066,561
• Publication Number:
  US 20080242960A1
• Time in Patent Office: 2,392 Days
• Field of Search: 600/323, 600/425
• US Class Current: 600/323
• CPC Class Codes: A61B 5/0073 by tomography, i.e. reconstruction of 3D images from 2D projections A61B5/0066 takes precedence
• CPC Class Codes: A61B 5/14551 for measuring blood gases
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes

Abstract

In optical tomography, a calibration of the data may be necessary for image reconstruction. According to an exemplary embodiment of the present invention, the object of interest is used for calibration, wherein the image data is acquired during a highly oxygenated phase of the object of interest and wherein the calibration data is acquired during a low oxygenated phase of the object of interest. This may provide for an improved calibration, resulting in improved image quality.

Claims

1. An optical examination apparatus for optical examination of an object of interest, the optical examination apparatus comprising:

a detector unit adapted for detecting first radiation and second radiation from the object of interest in response to light emitted from an optical radiation source propagating through the object of interest, the first radiation and the second radiation providing first detection data and second detection data, respectively; and

a determination unit adapted for determining spatially resolved information relating to the object of interest based on the first detection data and the second detection data,

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest,

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest, which is different from the first oxygen concentration, and

wherein the spatially resolved information relating to the object of interest is determined using a ratio of the first detection data and the second detection data for calibration.

2. The optical examination apparatus of claim 1, wherein the optical radiation source comprises a coupler adapted for coupling light emitted by a plurality of lasers or photodiodes, and emitting the coupled light to the object of interest.

3. The optical examination apparatus of claim 1, wherein the determination unit is adapted for reconstructing a two-dimensional or three-dimensional image of the object of interest based on the first detection data and the second detection data.

4. The optical examination apparatus of claim 1, wherein the first detection data corresponds to a systolic phase of the object of interest;

and wherein the second detection data corresponds to a diastolic phase of the object of interest.

5. The optical examination apparatus of claim 4, further comprising:

an electrocardiogram unit adapted for acquiring electrocardiogram data of the object of interest during the detection of the first radiation and the second radiation by the detector unit;

wherein the determination unit is adapted for identifying the systolic phase and therefore the first detection data and for identifying the diastolic phase and therefore the second detection data based on electrocardiogram data.

6. The optical examination apparatus of claim 1, wherein the determination unit is adapted for reconstructing blood dynamics of the object of interest on the basis of a temporal behaviour of the first radiation and the second radiation.

7. The optical examination apparatus of claim 1, wherein the detector unit is adapted for detecting, as the first detection data, first and second transmission data and, as the second detection data, first and second reflection data.

8. The optical examination apparatus of claim 1, adapted as an optical mammography apparatus.

9. The optical examination apparatus of claim 1, wherein the detector unit comprises a spatially resolving detector.

10. The optical examination apparatus of claim 1, wherein the detector unit comprises a frequency resolving detector or an energy resolving detector.

11. The optical examination apparatus of claim 1, wherein the detector unit comprises a time resolving detector.

12. The optical examination apparatus of claim 1, wherein the first radiation and the second radiation have the same wavelength.

13. The optical examination apparatus of claim 1, wherein the determination unit determines the spatially resolved information relating to the object of interest using the second detection data for calibration.

14. A method of examining an object of interest with an optical examination apparatus, the method comprising:

detecting light from the object of interest, responsive to optical radiation from an optical radiation source propagating through the object of interest, the detected light comprising first detection data and second detection data; and

determining spatially resolved information relating to the object of interest based on the first detection data and the second detection data,

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest while the primary optical radiation propagates through the object of interest,

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest, which is different from the first oxygen concentration, while the primary optical radiation propagates through the object of interest, and

wherein determining the spatially resolved information relating to the object of interest comprises;

determining a ratio between the first detection data and the second detection data for calibration; and

reconstructing an image of the object of interest based on the ratio.

18. The method of claim 14, further comprising:

acquiring electrocardiogram data of the object of interest during the detection of the light from the object of interest;

identifying a systolic phase based on the electrocardiogram data, the first detection data being detected during the systolic phase; and

identifying a diastolic phase based on the electrocardiogram data, the second detection data being detected during the diastolic phase.

15. An image processing device for examining an object of interest with an optical examination apparatus, the image processing device comprising:

a memory for storing first detection data and second detection data obtained from light propagating through the object of interest emitted by an optical radiation source; and

a determination unit adapted for determining spatially resolved information relating to the object of interest based on the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest; and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest, which is different from the first oxygen concentration.

16. A computer-readable medium, in which a computer program for examining an object of interest with an optical examination apparatus is stored which, when being executed by a processor, is adapted to carry out the steps of:

detecting light from the object of interest, responsive to optical radiation emitted by an optical radiation source and propagating through the object of interest, the detected light comprising first detection data and second detection data; and

determining spatially resolved information relating to the object of interest based on the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest while the optical radiation propagates through the object of interest; and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest, which is different from the first oxygen concentration, while the optical radiation propagates through the object of interest.

17. A program element of examining an object of interest, which, when being executed by a processor, is adapted to carry out the steps of:

detecting light from the object of interest, responsive to optical radiation emitted by an optical radiation source and propagating through the object of interest, the detected light comprising first detection data and second detection data; and

determining spatially resolved information relating to the object of interest based on the first detection data and the second detection data;

wherein the first detection data corresponds to a first oxygen concentration inside the object of interest while the optical radiation propagates through the object of interest; and

wherein the second detection data corresponds to a second oxygen concentration inside the object of interest, which is different from the first oxygen concentration, while the optical radiation propagates through the object of interest.