Ischemia detection based on combination of parameters associated with different sensors

• US 8,406,862 B2
• Filed: 11/12/2010
• Issued: 03/26/2013
• Est. Priority Date: 08/25/2010
• Status: Active Grant

• Current Assignee: Angel Medical Systems, Inc.
• Original Assignee: Angel Medical Systems, Inc.
• Inventors: Hopenfeld, Bruce
• Primary Examiner(s): Holmes, Rex R
• Application Number:
  US12/945,039
• Publication Number:
  US 20120053476A1
• Time in Patent Office: 865 Days
• Field of Search: 607 25- 26, 600508-509, 600515-519
• US Class Current: 600/516
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/0031 Implanted circuitry
• CPC Class Codes: A61B 5/364 Detecting abnormal ECG interval, e.g. extrasystoles, ectopic heartbeats

Abstract

An acute ischemia monitor is disclosed. The monitor, which includes an analog to digital convertor and a processor that performs beat detection, monitors the time course of a heart signal parameter, namely ST segment deviation, computed from an electrocardiogram. The device stores ST deviation statistics for multiple leads. For each lead, upper and lower ST deviation boundaries are computed. For each lead, current ST deviation values are compared with the statistical values to determine a metric indicative of the degree of abnormality of a current ST deviation value. The metric is equal to the difference between the current ST deviation value and the upper or lower boundary, normalized according to the dispersion of the ST deviation. Metrics from different leads are summed and compared to a threshold to determine whether the combined metric is indicative of a cardiac event.

Claims

1. A cardiac monitor for estimating the value of a heart signal parameter, the monitor comprising:

(a) a plurality of sensors for sensing first and second analog signals from a human heart;

(b) a device coupled to the plurality of sensors, the device having an analog-to-digital circuit system contained therein for digitizing the first and second analog signals to produce first and second digitized waveforms;

(c) a processor electrically coupled to the analog-to-digital circuit system, said processor configured to;

(i) compute first and second pluralities of values of a heart signal parameter from the first and second digitized waveforms respectively, wherein first and second subsets of the first and second pluralities of values are characterized by first and second statistical distributions respectively that are characterized by first and second dispersions respectively;

(ii) compute a first metric based on the first plurality of values normalized according to the first dispersion, wherein the first metric is indicative of the distance between at least one of the first plurality of values and a statistical parameter associated with the first statistical distribution;

(iii) compute a second metric based on the second plurality of values normalized according to the second dispersion, wherein the second metric is indicative of the distance between at least one of the second plurality of values and a statistical parameter associated with the second statistical distribution; and

(iv) apply a test to detect a cardiac event, wherein the test is based on a third metric that is a function of both the first and second metrics.

2. The cardiac monitor of claim 1 wherein the third metric is a sum of the first and second metrics.

3. The cardiac monitor of claim 2 wherein the test is a comparison of the third metric with a threshold.

4. The cardiac monitor of claim 1 wherein the processor is configured to compute a filtered value based on the first plurality of values, and wherein the first metric is indicative of the distance between the filtered value and the statistical parameter associated with the first statistical distribution.

5. The cardiac monitor of claim 1 wherein the first plurality of values are normalized according to the first dispersion by dividing a numerator by the first dispersion, wherein the numerator is based on at least one of the first plurality of values.

6. The cardiac monitor of claim 1 wherein the statistical parameter associated with the first statistical distribution is a boundary of the first statistical distribution.

7. The cardiac monitor of claim 1 wherein the heart signal parameter is ST segment deviation.

8. The cardiac monitor of claim 1 wherein the first dispersion is based on the range of the first statistical distribution.

9. The cardiac monitor of claim 8 wherein the first dispersion is equal to the distance between a boundary of the first statistical distribution and the median of the statistical distribution.

10. The cardiac monitor of claim 1 wherein the first statistical distribution is one of a plurality of statistical distributions that is selected according to heart rate.

11. The cardiac monitor of claim 1 wherein the first metric is based on a third subset of the first plurality of values computed after all of the values in the first subset were computed.

12. A cardiac monitor for estimating the value of a heart signal parameter, the monitor comprising:

(a) a plurality of sensors for sensing first and second analog signals from a human heart;

(b) a device coupled to the plurality of sensors, the device having an analog-to-digital circuit system contained therein for digitizing the first and second analog signals to produce first and second digitized waveforms;

(c) a processor electrically coupled to the analog-to-digital circuit system, said processor configured to;

(i) compute first and second pluralities of values of a heart signal parameter from the first and second digitized waveforms respectively, wherein first and second subsets of the first and second pluralities of values are characterized by first and second statistical distributions respectively that are characterized by first and second dispersions respectively;

(ii) compute a first metric based on the first plurality of values and a boundary of the first statistical distribution, such that the first metric is indicative of the distance between the boundary of the first statistical distribution and at least one of the first plurality of values;

(iii) compute a second metric based on the second plurality of values and a boundary of the second statistical distribution, such that the second metric is indicative of the distance between the boundary of the second statistical distribution and at least one of the second plurality of values; and

(iv) apply a test to detect a cardiac event, wherein the test is based on a third metric that is a function of both the first and second metrics.

13. The cardiac monitor of claim 12 wherein the boundary of the first statistical distribution is determined by searching for heart signal parameter value beyond which there are less than a specified number of elements.

14. The cardiac monitor of claim 12 wherein the first metric is normalized according to the first dispersion.

15. The cardiac monitor of claim 12 wherein the test is a comparison of the third metric with a threshold.

16. A cardiac monitor for estimating the value of a heart signal parameter, the monitor comprising:

(a) a plurality of sensors for sensing first and second analog signals from a human heart;

(b) a device coupled to the plurality of sensors, the device having an analog-to-digital circuit system contained therein for digitizing the first and second analog signals to produce first and second digitized waveforms;

(c) a processor electrically coupled to the analog-to-digital circuit system, said processor configured to;

(i) compute first and second pluralities of values of a heart signal parameter from the first and second digitized waveforms respectively, wherein first and second subsets of the first and second pluralities of values are characterized by first and second statistical distributions respectively;

(ii) compute a first value of the heart signal parameter based on at least one of the first plurality of values, wherein the first value is characterized by a polarity depending on whether the first value is above or below a measure of average value of the first statistical distribution;

(iii) computing a first metric based on the first value, wherein the value of the first metric depends on the polarity of the first value;

(iv) compute a second value of the heart signal parameter based on at least one of the second plurality of values, wherein the second value is characterized by a polarity depending on whether the second value is above or below a measure of average value of the second statistical distribution;

(v) computing a second metric based on the second value, wherein the value of the second metric depends on the polarity of the second value; and

(vi) apply a test to detect a cardiac event, wherein the test is based on a third metric that is a function of both the first and second metrics.

17. The cardiac monitor of claim 16 wherein the test is a comparison of the third metric with a threshold that is selected according to both the polarity of the first value and the polarity of the second value.

18. The cardiac monitor of claim 16 wherein the first metric is an absolute distance.

19. The cardiac monitor of claim 16 wherein the first metric is a relative distance distance that depends on the dispersion of the first statistical distribution.

20. The cardiac monitor of claim 16 wherein the measure of average value of the first statistical distribution is a median value.