Post-acute electrical stimulation treatment of adverse cerebrovascular events
First Claim
1. A method for treatment, comprising:
- identifying that a subject has suffered from an adverse cerebrovascular event, excluding Alzheimer'"'"'s disease and Parkinson'"'"'s disease;
responsively to the identifying, applying, beginning at least three hours after the event, electrical stimulation to a site of the subject selected from the group consisting of;
a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve; and
configuring the stimulation to excite nervous tissue of the site at a strength (a) sufficient to induce at least one neuroprotective occurrence selected from the group consisting of;
an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances, and (b) insufficient to induce a substantial increase in permeability of a blood-brain barrier (BBB) of the subject.
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Accused Products
Abstract
A method for treatment is provided, including identifying that a subject has suffered from an adverse cerebrovascular event, excluding Alzheimer'"'"'s disease and Parkinson'"'"'s disease. Responsively to the identifying, beginning at least nine hours after the event, electrical stimulation is applied to a site of the subject selected from the group consisting of: a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve. The stimulation is configured to excite nervous tissue of the site at a strength sufficient to induce at least an increase in cerebral blood flow (CBF) and/or a release of one or more neuroprotective substances.
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Citations
10 Claims
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1. A method for treatment, comprising:
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identifying that a subject has suffered from an adverse cerebrovascular event, excluding Alzheimer'"'"'s disease and Parkinson'"'"'s disease; responsively to the identifying, applying, beginning at least three hours after the event, electrical stimulation to a site of the subject selected from the group consisting of;
a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve; andconfiguring the stimulation to excite nervous tissue of the site at a strength (a) sufficient to induce at least one neuroprotective occurrence selected from the group consisting of;
an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances, and (b) insufficient to induce a substantial increase in permeability of a blood-brain barrier (BBB) of the subject. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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Specification
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- Resources
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Current AssigneeBrainsGate Ltd.
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Original AssigneeBrainsGate Ltd.
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InventorsLamensdorf, Itschak, Dayan, Avinoam, Altman, Hernan
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Primary Examiner(s)Koharski, Christopher D
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Assistant Examiner(s)D ABREU, MICHAEL JOSEPH
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Application NumberUS13/223,929Publication NumberTime in Patent Office572 DaysField of Search607/2, 607/3, 607/45, 607/46US Class Current607/2CPC Class CodesA61N 1/0551 Spinal or peripheral nerve ...A61N 1/36017 with leads or electrodes pe...A61N 1/36082 Cognitive or psychiatric ap...
