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Post-acute electrical stimulation treatment of adverse cerebrovascular events

  • US 8,406,869 B2
  • Filed: 09/01/2011
  • Issued: 03/26/2013
  • Est. Priority Date: 08/19/2005
  • Status: Active Grant
First Claim
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1. A method for treatment, comprising:

  • identifying that a subject has suffered from an adverse cerebrovascular event, excluding Alzheimer'"'"'s disease and Parkinson'"'"'s disease;

    responsively to the identifying, applying, beginning at least three hours after the event, electrical stimulation to a site of the subject selected from the group consisting of;

    a sphenopalatine ganglion (SPG), a greater palatine nerve, a lesser palatine nerve, a sphenopalatine nerve, a communicating branch between a maxillary nerve and an SPG, an otic ganglion, an afferent fiber going into the otic ganglion, an efferent fiber going out of the otic ganglion, an infraorbital nerve, a vidian nerve, a greater superficial petrosal nerve, and a lesser deep petrosal nerve; and

    configuring the stimulation to excite nervous tissue of the site at a strength (a) sufficient to induce at least one neuroprotective occurrence selected from the group consisting of;

    an increase in cerebral blood flow (CBF) of the subject, and a release of one or more neuroprotective substances, and (b) insufficient to induce a substantial increase in permeability of a blood-brain barrier (BBB) of the subject.

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