Variable voltage compliance for current output generator

• US 8,406,881 B2
• Filed: 08/29/2011
• Issued: 03/26/2013
• Est. Priority Date: 07/13/2006
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Haefner, Paul A.
• Primary Examiner(s): Patel, Niketa
• Assistant Examiner(s): EL-KAISSI, HIBA CARINE
• Application Number:
  US13/220,215
• Publication Number:
  US 20110313492A1
• Time in Patent Office: 575 Days
• Field of Search: 607 2- 8, 607/25, 607/115, 607/116, 607/62
• US Class Current: 607/28
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/056 Transvascular endocardial electrode systems
• CPC Class Codes: A61N 1/36053 adapted for vagal stimulation A61N1/36114 takes precedence
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3615 Intensity
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3706 Pacemaker parameters stimulation threshold A61N1/371

Abstract

A system for providing stimulation current in implantable medical devices is provided. One aspect of this disclosure relates to an apparatus including a power supply terminal adapted to be connected to a power supply. The apparatus embodiment also includes circuitry connected to the power supply terminal and adapted to detect a parameter dependent on tissue/electrode impedance. The apparatus embodiment further includes a current output pulse generator adapted to deliver electrical therapy. The current generator includes an adjustable compliance voltage source connected to the power supply terminal. The compliance voltage source has a programmable amplitude and is adapted to provide different potentials for different tissue/electrode interface impedances. According to various embodiments, the apparatus embodiment also includes at least one stimulating electrode, and the current generator is adapted to deliver electrical therapy using the electrode. Other aspects and embodiments are provided herein.

Claims

1. An apparatus for delivering electrical neural stimulation therapy to a patient, the apparatus comprising:

a power supply;

circuitry connected to the power supply and adapted to detect tissue/electrode interface impedances;

at least one stimulating electrode, wherein the circuitry includes a charged capacitor adapted to be electrically connected to the at least one stimulating electrode; and

a current output pulse generator connected to the at least one stimulating electrode, the generator comprising a programmed amplitude of stimulation current, wherein the generator is configured to deliver electrical neural stimulation therapy at the programmed amplitude, the generator further comprising;

an adjustable compliance voltage source connected to the power supply, the voltage source configured to provide an adjustable voltage level and different potentials for the different tissue/electrode interface impedances, the voltage source comprising;

a supply capacitor;

two variable current sources connected in parallel with the supply capacitor; and

switches configured to control the delivery of electrical neural stimulation therapy, wherein the switches are connected to the current sources and supply capacitor, wherein the pulse generator is configured to receive the detected impedances, maintain the programmed amplitude of stimulation current for the different tissue/electrode interface impedances and adjust the compliance voltage source by adjusting the voltage level based on the programmed amplitude of the stimulation current and the detected impedances; and

wherein the charged capacitor is adapted to be electrically connected to the at least one stimulating electrode for a pre-determined amount of time, and wherein the tissue/electrode interface impedances are determined by measuring a voltage difference across the charged capacitor before and after connecting it to the at least one electrode.

2. The apparatus of claim 1, wherein the voltage source is adjustable over a range from 1V to 100V.

3. The apparatus of claim 1, wherein the circuitry is configured to detect tissue/electrode interface impedances in a range of impedance values from 100Ω

to 2 kΩ

.

4. The apparatus of claim 1, wherein the current output pulse generator is configured to deliver electrical current over a range from 5 μ

A to 10 mA.

5. The apparatus of claim 1, wherein the apparatus is fully implantable.

6. The apparatus of claim 1, wherein the apparatus is partially implantable, and current output pulse generator of the apparatus is implantable.

7. The apparatus of claim 1, further comprising an enclosure configured to house the power supply, the current output pulse generator, the adjustable compliance voltage source and the circuitry.

8. The apparatus of claim 1, further comprising an enclosure configured to house the current output pulse generator and the circuitry.

9. The apparatus of claim 1, further comprising an electronic feedback loop, wherein the apparatus is configured to adjust the voltage source using the electronic feedback loop to maintain a fixed voltage differential between the compliance voltage level and a load voltage.

10. The apparatus of claim 1, wherein the apparatus is configured to communicate with an external device to adjust the compliance voltage source.

11. The apparatus of claim 10, wherein the external device is part of an advanced patient management system (APM).

12. The apparatus of claim 1, further comprising a controller adapted to receive the detected impedances, maintain the programmed amplitude of stimulation current for the different tissue/electrode interface impedances.

13. The apparatus of claim 1, further comprising a telemetry circuit.

14. An apparatus for delivering electrical neural stimulation therapy to a patient, the apparatus comprising:

a power supply;

circuitry connected to the power supply and adapted to detect tissue/electrode interface impedances;

at least one stimulating electrode, wherein the circuitry includes a charged capacitor adapted to be electrically connected to the at least one stimulating electrode; and

a current output pulse generator connected to the at least one stimulating electrode, the generator comprising a programmed amplitude of stimulation current, wherein the generator is configured to deliver electrical neural stimulation therapy at the programmed amplitude, the generator further comprising;

an adjustable compliance voltage source connected to the power supply, the voltage source configured to provide an adjustable voltage level and different potentials for the different tissue/electrode interface impedances, the voltage source comprising;

a supply capacitor;

two variable current sources connected in parallel with the supply capacitor; and

switches configured to control the delivery of electrical neural stimulation therapy, wherein the switches are connected to the current sources and supply capacitor, wherein the pulse generator is configured to receive the detected impedances, maintain the programmed amplitude of stimulation current for the different tissue/electrode interface impedances and adjust the compliance voltage source by adjusting the voltage level based on the programmed amplitude of the stimulation current and the detected impedances; and

wherein the charged capacitor is adapted to be connected to the stimulating electrodes until a voltage difference across the charged capacitor achieves a predetermined value, and wherein the tissue/electrode interface impedances are determined by measuring an amount of time to reach the predetermined value.

15. The apparatus of claim 14, wherein the neural stimulation therapy includes vagal stimulation therapy.

16. The apparatus of claim 14, wherein the at least one stimulating electrode includes a transvascular electrode.

17. The apparatus of claim 14, wherein the at least one stimulating electrode includes nerve cuff electrode.

18. The apparatus of claim 14, wherein the apparatus is connected to a memory with a look-up table stored therein, wherein the look-up table includes tissue/electrode interface impedance and desired level of stimulation current, wherein the apparatus is configured to adjust the voltage source using the look-up table the circuitry includes a charged capacitor adapted to be electrically connected to the stimulating electrodes.