Devices for delivering substances through an extra-anatomic opening created in an airway

• US 8,409,167 B2
• Filed: 10/05/2006
• Issued: 04/02/2013
• Est. Priority Date: 07/19/2004
• Status: Active Grant

• Current Assignee: Broncus Medical Incorporated
• Original Assignee: Broncus Medical Incorporated
• Inventors: Roschak, Edmund J.
• Primary Examiner(s): Mehta, Bhisma
• Application Number:
  US11/538,950
• Publication Number:
  US 20080086107A1
• Time in Patent Office: 2,371 Days
• Field of Search: 604/500, 604/506, 604/507, 604/508, 604/510
• US Class Current: 604/506
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2210/0076 multilayered, e.g. laminated structures
• CPC Class Codes: A61F 2220/0075 sutured, ligatured or stitched, retained or tied with a rope, string, thread, wire or cable
• CPC Class Codes: A61F 2230/005 Rosette-shaped, e.g. star-shaped
• CPC Class Codes: A61F 2230/0078 hyperboloidal
• CPC Class Codes: A61M 2025/1081 having sheaths or the like for covering the balloon but not forming a permanent part of the balloon, e.g. retractable, dissolvable or tearable sheaths
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/0082 Catheter tip comprising a tool
• CPC Class Codes: A61M 25/10 Balloon catheters A61M25/0125 takes precedence; embolectomy A61B17/22032; retractors A61B17/02; inflatable balloons for placing stents or stent-grafts A61F2/958 ; stomach balloons for treatment of obesity A61F5/0003; oesophagal tubes A61J15/00
• CPC Class Codes: A61M 29/00 Dilators with or without means for introducing media, e.g. remedies instruments for performing visual medical inspections of cavities or tubes of the body A61B1/00
• CPC Class Codes: A61M 29/02 Dilators made of swellable material balloon catheters for angioplasty A61M25/104
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008
• CPC Class Codes: A61M 5/158 Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
• CPC Class Codes: A61N 1/327 for enhancing the absorption properties of tissue, e.g. by electroporation

Abstract

Devices and methods for delivering substances to lung tissue through an extra-anatomic passage created in an airway.

Claims

1. A method of treating diseased lung tissue in a lung, the method comprising:

advancing a delivery catheter through a natural respiratory opening and into the lung;

creating and maintaining an extra-anatomic opening in an airway wall at a target site such that patency of the extra-anatomic opening is artificially extended beyond a natural healing response; and

delivering a substance through the extra-anatomic opening to treat a region of diseased tissue beyond the airway wall in the lung.

2. The method of claim 1, further comprising:

identifying the region of diseased tissue prior to delivering the substance; and

selecting the target site.

3. The method of claim 2, where identifying the region in the lung having diseased tissue comprises locating a tumor in the lung.

4. The method of claim 3, further comprising delivering the substance through the extra-anatomic opening to treat the tumor.

5. The method of claim 2, where identifying the region in the lung having diseased tissue comprises locating a region of trapped gasses.

6. The method of claim 5, further comprising delivering the substance through the extra-anatomic opening to collapse the region of the lung containing the collapsed gasses.

7. The method of claim 2, where identifying the region in the lung having diseased tissue comprises locating the region using an imaging method selected from radiography, computer tomography, ultrasound, Doppler, MRI, PET and acoustic imaging.

8. The method of claim 2, where selecting the target site comprises scanning for the presence of a blood vessel in the airway wall to avoid puncturing the blood vessel during creation of the extra-anatomic opening.

9. The method of claim 8, where scanning the target site comprises using a modality selected from the group consisting of visual inspection, x-ray, ultrasound, Doppler, acoustic, MRI, PET, and computed tomography (CT) scans.

10. The method of claim 1, further comprising inserting an implant within the extra-anatomic opening.

11. The method of claim 10, further comprising removing the implant subsequently to delivering the substance.

12. The method of claim 1, wherein creating the extra-anatomic opening comprises using a needle-like member which punctures the tissue to create the extra-anatomic opening.

13. The method of claim 12, where the needle-like member delivers the substance.

14. The method of claim 1, where the substance comprises a substance selected from the group consisting of antimetabolites, antithrobotics, anticoagulants, antiplatelet agents, thorombolytics, antiproliferatives, anti-inflammatories, agents that inhibit hyperplasia, agents that inhibit restenosis, smooth muscle cell inhibitors, growth factors, growth factor inhibitors, cell adhesion inhibitors, cell adhesion promoters and a combination thereof.

15. The method of claim 1, where the substance comprises a substance selected from the group consisting of analgesics, anticonvulsives, antibiotics, antimicrobials, antineoplastics, Histamine 2 antagonists, steroids, non-steroidal anti-inflammatories, hormones, immunomodulators, mast cell stabilizers, nucleoside analogues, respiratory agents, antihypertensives, antihistamines, ACE inhibitors, cell growth factors, nerve growth factors, anti-angiogenic agents or angiogenesis inhibitors, tissue irritants, a compound comprising talc, poisons, cytotoxic agents, silver, aluminum, zinc, platinum, arsenic, epithelial growth factors, pyrolitic carbon, titanium-nitride-oxide, taxanes, fibrinogen, collagen, thrombin, phosphorylcholine, heparin, rapamycin, radioactive 188Re and 32P, silver nitrate, dactinomycin, sirolimus, everolimus, Abt-578, tacrolimus, camptothecin, etoposide, vincristine, mitomycin, fluorouracil, or cell adhesion peptides, and a combination thereof.

16. The method of claim 1, where maintaining the extra anatomic opening occurs by an act selected from the group consisting of applying a bio-active substance and implanting a conduit.

17. A method for locating and treating cancerous tissue in a lung comprising:

advancing a device through an oral opening and into an airway within the lung;

locating a target site along an airway wall, the target site being in the vicinity of the cancerous tissue; and

delivering a substance through an existing surgically created opening to treat the cancerous tissue beyond the airway wall in the lung where the existing surgically created opening was previously created such that patency of the surgically created opening is extended beyond at least creation of the surgically created opening.

18. The method of claim 17, further comprising sensing for a blood vessel prior to said delivering step.

19. The method of claim 17, further comprising preventing closure of the surgical opening wherein said preventing step is performed using a combination of mechanical and biochemical means.

20. The method of claim 19 where said delivering step comprises inserting an instrument through the surgical opening and injecting said substance from said instrument to the tissue.

21. The method of claim 17 where the tissue is a tumor.

22. The method of claim 17, where previously creating the existing surgically created opening included an act selected from the group consisting of applying a bio-active substance;

dilating;

piercing, and implanting a conduit.