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Methods for treating bone loss with antibodies to OPGL

  • US 8,409,578 B2
  • Filed: 11/14/2011
  • Issued: 04/02/2013
  • Est. Priority Date: 06/26/2001
  • Status: Expired due to Term
First Claim
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1. A method of treating bone loss in a patient, comprising administering an antibody comprising a heavy chain and a light chain, wherein the heavy chain comprises CDR1, CDR2, and CDR3 of SEQ ID NO:

  • 13 and the light chain comprises CDR1, CDR2, and CDR3 of SEQ ID NO;

    14, wherein the heavy chain and light chain form an antibody that interacts with a human osteoprotegerin ligand (OPGL) and inhibits binding of human OPGL to an osteoclast differentiation and activation receptor (ODAR).

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