Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods

• US 8,409,607 B2
• Filed: 02/11/2008
• Issued: 04/02/2013
• Est. Priority Date: 04/30/2004
• Status: Active Grant

• Current Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Original Assignee: Allergan, Inc. (Canada) (Abbvie Incorporated)
• Inventors: Hughes, Patrick M., Malone, Thomas C., De Vries, Gerald W., Edelman, Jeffery L., Chang-Lin, Joan-En, Shiah, Jane-Guo, Nivaggioli, Thierry
• Primary Examiner(s): AZPURU, CARLOS A
• Application Number:
  US12/029,425
• Publication Number:
  US 20080254096A1
• Time in Patent Office: 1,877 Days
• Field of Search: None
• US Class Current: 424/428
• CPC Class Codes: A61K 9/0051 Ocular inserts, ocular implants
• CPC Class Codes: A61K 9/1647 Polyesters, e.g. poly(lactide-co-glycolide)
• CPC Class Codes: A61P 27/02 Ophthalmic agents
• CPC Class Codes: A61P 27/06 Antiglaucoma agents or miotics
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: Y10T 428/2985 Solid-walled microcapsule from synthetic polymer

Abstract

Biocompatible intraocular implants include a tyrosine kinase inhibitor and a biodegradable polymer that is effective to facilitate release of the tyrosine kinase inhibitor into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions.

Claims

1. A method of treating an ocular condition of an eye of a patient, comprising the step of placing an extruded biodegradable intraocular implant in an eye of the patient, the implant comprising a tyrosine kinase inhibitor and a biodegradable polymer matrix, wherein the implant degrades at a rate effective to sustain release of an amount of the tyrosine kinase inhibitor from the implant effective to treat the ocular condition, wherein the biodegradable polymer matrix consists essentially of a polycaprolactone having a molecular weight of about 15 kilodaltons, and wherein the implant releases the tyrosine kinase inhibitor for at least about 70 days at a substantially linear rate.

2. The method of claim 1, wherein the ocular condition is glaucoma.

3. The method of claim 1, wherein the implant is placed in the posterior of the eye.

4. The method of claim 1, wherein the implant is placed in the eye with a trocar.

5. The method of claim 1, wherein the implant is placed in the eye with a syringe.

6. The method of claim 1, further comprising a step of administering a therapeutic agent in addition to the tyrosine kinase inhibitor to the patient.

7. The method of claim 1, wherein the ocular condition is selected from the group consisting of glaucoma, proliferative vitreoretinopathy, diabetic retinopathy, non-exudative age related macular degeneration, exudative age related macular degeneration, and retinopathy of prematurity.

8. The method of claim 7, wherein the implant is placed in the vitreous of the eye.