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Microgranules insoluble in gastric fluid, method for obtaining same and pharmaceutical preparations

  • US 8,409,612 B1
  • Filed: 05/19/2000
  • Issued: 04/02/2013
  • Est. Priority Date: 05/21/1999
  • Status: Expired due to Fees
First Claim
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1. A microgranule comprising a gastric proton pump inhibitor, with the exception of omeprazole, comprising an active layer comprising the proton pump inhibitor and an outer layer for protection in gastric fluid, wherein:

  • (A) the active layer is applied to a neutral nucleus;

    (B) the active layer comprises at least one hydrophobic substance chosen from silicone oils and present in the active layer in an amount of between 5 and 40% by weight of the gastric proton pump inhibitor;

    (C) and the layer for protection in gastric fluid comprises at least one hydrophobic substance chosen from glycerides and present in the layer for protection in gastric fluid in an amount of 5 to 20% by weight of the protective layer; and

    further wherein the microgranule has no alkaline compound and no ionic surfactant.

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