Preservation of ergothioneine

• US 8,410,156 B2
• Filed: 01/30/2009
• Issued: 04/02/2013
• Est. Priority Date: 01/30/2009
• Status: Active Grant

• Current Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Original Assignee: ELC Management LLC (The Estee Lauder Companies Inc.)
• Inventors: Yarosh, Daniel B.
• Primary Examiner(s): Anderson, James D
• Assistant Examiner(s): SPRINGER, STEPHANIE K
• Application Number:
  US12/362,594
• Publication Number:
  US 20100197750A1
• Time in Patent Office: 1,523 Days
• Field of Search: None
• US Class Current: 514/398
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/417 Imidazole-alkylamines, e.g. histamine, phentolamine
• CPC Class Codes: A61K 31/4172 Imidazole-alkanecarboxylic acids, e.g. histidine
• CPC Class Codes: A61K 45/06 Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
• CPC Class Codes: A61K 47/12 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/19 containing inorganic ingredients
• CPC Class Codes: A61K 8/23 Sulfur; Selenium; Tellurium; Compounds thereof
• CPC Class Codes: A61K 8/24 Phosphorous; Compounds thereof
• CPC Class Codes: A61K 8/36 Carboxylic acids; Salts or anhydrides thereof
• CPC Class Codes: A61K 8/365 Hydroxycarboxylic acids; Ketocarboxylic acids
• CPC Class Codes: A61K 8/4946 Imidazoles or their condensed derivatives, e.g. benzimidazoles
• CPC Class Codes: A61K 8/676 Ascorbic acid, i.e. vitamin C
• CPC Class Codes: A61K 9/0014 Skin, i.e. galenical aspects of topical compositions non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00
• CPC Class Codes: A61P 17/00 Drugs for dermatological disorders
• CPC Class Codes: A61Q 19/00 Preparations for care of the skin

Abstract

Compositions comprising ergothioneine and a trimethylamine absorber are provided. Also provided are methods for preventing, reducing or minimizing the fishy, amine odor, due to trimethylamine, that is associated with the processing and/or storage of a preparation containing ergothioneine, by combining with the ergothioneine, during processing or prior to storage, a trimethylamine absorber in an amount sufficient to prevent the detection of any trimethylamine odor by the human nose. A method is further provided for ameliorating the methylamine odor associated with an aqueous ergothioneine-containing preparation after it has developed a fishy trimethylamine odor.

Claims

1. An aqueous-containing treatment composition comprising ergothioneine wherein the improvement is supplying the ergothioneine to the treatment composition in the form of a pre-blend comprising ergothioneine and at least one trimethylamine absorber in an amount sufficient to ameliorate any trimethylamine odor in the treatment composition when the treatment composition is used for its intended purpose, wherein the trimethylamine absorber is a sulfur dioxide donor compound selected from the group consisting of sodium sulfite, sodium bisulfate, sodium metabisulfite, potassium bisulfate, potassium metabisulfite and calcium bisulfate.

2. The treatment composition of claim 1 which is a topical, ingestible or injectable composition.

3. The treatment composition of claim 2 which is a topical cosmetic or pharmaceutical composition.

4. The treatment composition of claim 1 which comprises ergothioneine at a concentration of greater than 2 mM (w/v).

5. A preblend composition consisting essentially of ergothioneine at a concentration of greater than 2 mM (w/v) and a trimethylamine absorber selected from the group consisting of sodium sulfite, sodium bisulfate, sodium metabisulfite, potassium bisulfate, potassium metabisulfite and calcium bisulfate.

6. A method of ameliorating a fishy, amine odor associated with the processing and/or storage of an aqueous-containing preparation containing greater than 2 mM (w/v) ergothioneine, said method comprising combining with the ergothioneine, during the processing and/or prior to the storage of the preparation, a trimethylamine absorber in an amount sufficient to ameliorate the detection of the fishy, amine odor in the composition when it is used for its intended purpose, wherein the trimethylamine absorber is a sulfur dioxide donor compound selected from the group consisting of sodium sulfite, sodium bisulfate, sodium metabisulfite, potassium bisulfate, potassium metabisulfite and calcium bisulfate.

7. The method of claim 6 wherein the ergothioneine is supplied to the aqueous-containing preparation in the form of a pre-blend comprising ergothioneine and at least one trimethylamine absorber in an amount sufficient to ameliorate any trimethylamine odor in the aqueous-containing preparation when it is used for its intended purpose, wherein the trimethylamine absorber is a sulfur dioxide donor compound selected from the group consisting of sodium sulfite, sodium bisulfate, sodium metabisulfite, potassium bisulfate, potassium metabisulfite and calcium bisulfate.

8. A method of treating an aqueous solution of ergothioneine or an aqueous-containing ergothioneine-containing mixture having a detectable fishy, trimethylamine odor associated therewith, said method comprising introducing into the solution of ergothioneine or the ergothioneine-containing mixture in need of such treatment a trimethylamine absorber in an amount sufficient to ameliorate the detection by the human nose of the fishy, trimethylamine odor, wherein the trimethylamine absorber is a sulfur dioxide donor compound selected from the group consisting of sodium sulfite, sodium bisulfate, sodium metabisulfite, potassium bisulfate, potassium metabisulfite and calcium bisulfate.

9. A composition comprising ergothioneine and at least one trimethylamine absorber selected from the group consisting of sodium sulfite, sodium bisulfate, sodium metabisulfite, potassium bisulfate, potassium metabisulfite and calcium bisulfate, wherein the ergothioneine and the at least one trimethylamine absorber are present in the composition in amounts sufficient to permit the composition to retain an innocuous odor during preparation and/or storage.