Crosslinked polyalkyleneimine hydrogels with tunable degradation rates
First Claim
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1. A polymeric composition, comprising an activated polyethylene glycol diacid derivative, and a covalent crosslinking agent;
- wherein the covalent crosslinking agent is polyethyleneimine having a weight average molecular weight of about 400 to about 2000 Daltons;
the molar ratio of activated esters on the polyethylene glycol diacid derivative to primary amines on the polyethyleneimine is within a range of about 0.5;
1 to about 1.5;
1; and
the activated polyethylene glycol diacid derivative is represented by formula I;
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Abstract
One aspect of the present invention relates to methods of sealing a wound or tissue plane or filling a void space, or securing meshes, films or other devices within the body. In certain embodiments, the wound is an ophthalmic, pleural or dural wound, or a hernia repair mesh. Remarkably, disclosed herein is the discovery that the use of certain crosslinkers in combination with polyalkyleneimines at specific concentrations can result in hydrogels with tunable degradation properties.
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22 Claims
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1. A polymeric composition, comprising an activated polyethylene glycol diacid derivative, and a covalent crosslinking agent;
- wherein the covalent crosslinking agent is polyethyleneimine having a weight average molecular weight of about 400 to about 2000 Daltons;
the molar ratio of activated esters on the polyethylene glycol diacid derivative to primary amines on the polyethyleneimine is within a range of about 0.5;
1 to about 1.5;
1; and
the activated polyethylene glycol diacid derivative is represented by formula I;
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
- wherein the covalent crosslinking agent is polyethyleneimine having a weight average molecular weight of about 400 to about 2000 Daltons;
Specification