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Crosslinked polyalkyleneimine hydrogels with tunable degradation rates

  • US 8,410,189 B2
  • Filed: 02/13/2009
  • Issued: 04/02/2013
  • Est. Priority Date: 02/13/2008
  • Status: Active Grant
First Claim
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1. A polymeric composition, comprising an activated polyethylene glycol diacid derivative, and a covalent crosslinking agent;

  • wherein the covalent crosslinking agent is polyethyleneimine having a weight average molecular weight of about 400 to about 2000 Daltons;

    the molar ratio of activated esters on the polyethylene glycol diacid derivative to primary amines on the polyethyleneimine is within a range of about 0.5;

    1 to about 1.5;

    1; and

    the activated polyethylene glycol diacid derivative is represented by formula I;

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