Wettable hydrogel materials for use in ophthalmic applications and methods
First Claim
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1. A method of manufacturing a hydrogel contact lens body, comprising:
- (i) providing a polymerizable composition comprisingat least one polymerizable form of a boronic acid, boronic ester, boronic anhydride, or combination thereof;
at least one hydrophilic monomer, andat least one crosslinking agent; and
(ii) cast molding the polymerizable composition in a contact lens mold assembly to form a polymerized reaction product that is an uncomplexed hydrogel lens body formed of a copolymer comprisingpolymerized units of the at least one polymerizable form of the boronic acid, boronic ester, boronic anhydride or combination thereof,polymerized units of the at least one hydrophilic monomer, andcrosslinks formed by the at least one crosslinking agent;
wherein the uncomplexed hydrogel lens body hasan advancing contact angle less than about 120°
,a modulus less than about 1.6 MPa,an ionoflux less than about 7×
10−
3 mm2/min.,an oxygen permeability of less than about 120 Barrers, andan equilibrium water content of at least about 30%.
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Abstract
A contact lens is provided that has extended and rechargeable wettability. The contact lens includes a lens body that is a reaction product of a polymerizable composition. A first polyhydric alcohol having a 1,2 diol or 1,3 diol moiety is present on a lens surface of the lens body. A contact lens package including the contact lens, and methods of producing and using the contact lens, are also provided.
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Citations
22 Claims
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1. A method of manufacturing a hydrogel contact lens body, comprising:
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(i) providing a polymerizable composition comprising at least one polymerizable form of a boronic acid, boronic ester, boronic anhydride, or combination thereof; at least one hydrophilic monomer, and at least one crosslinking agent; and (ii) cast molding the polymerizable composition in a contact lens mold assembly to form a polymerized reaction product that is an uncomplexed hydrogel lens body formed of a copolymer comprising polymerized units of the at least one polymerizable form of the boronic acid, boronic ester, boronic anhydride or combination thereof, polymerized units of the at least one hydrophilic monomer, and crosslinks formed by the at least one crosslinking agent; wherein the uncomplexed hydrogel lens body has an advancing contact angle less than about 120°
,a modulus less than about 1.6 MPa, an ionoflux less than about 7×
10−
3 mm2/min.,an oxygen permeability of less than about 120 Barrers, and an equilibrium water content of at least about 30%. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 20, 21, 22)
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15. A hydrogel lens body, comprising:
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a cast molded polymerized reaction product of a polymerizable composition reacted in a contact lens mold assembly to produce a hydrogel contact lens body, the polymerizable composition comprising at least one polymerizable form of a boronic acid, boronic ester, boronic anhydride, or combination thereof; at least one hydrophilic monomer; and at least one crosslinking agent; the hydrogel lens body formed of a copolymer comprising polymerized units of the at least one polymerizable form of the boronic acid, boronic ester, boronic anhydride or combination thereof, polymerized units of the at least one hydrophilic monomer, and crosslinks formed by the at least one crosslinking agent; wherein at least a portion of boronic acid moieties present in the copolymer of the lens body are complexed with a wetting agent, and the lens body is a complexed lens body, wherein an uncomplexed lens body has an advancing contact angle less than about 120°
,a modulus less than about 1.6 MPa, an ionoflux less than about 7×
10−
3 mm2/min.,an oxygen permeability of less than about 120 Barrers, and an equilibrium water content of at least about 30%; and the complexed lens body has an advancing contact angle at least 10% less than an advancing contact angle of the uncomplexed lens body, as determined by testing hydrated lens bodies soaked in phosphate buffered saline for at least 6 hours. - View Dependent Claims (16, 17, 18, 19)
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Specification