Microelectronic sensor device for optical examinations on a wetted surface

• US 8,411,274 B2
• Filed: 06/24/2008
• Issued: 04/02/2013
• Est. Priority Date: 06/28/2007
• Status: Active Grant

• Current Assignee: Siemens Healthcare Nederland B.V. (Siemens AG)
• Original Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Inventors: Verschuren, Coen Adrianus, Immink, Albert Hendrik Jan
• Primary Examiner(s): STAFIRA, MICHAEL PATRICK
• Application Number:
  US12/666,814
• Publication Number:
  US 20100328654A1
• Time in Patent Office: 1,743 Days
• Field of Search: 356445-448
• US Class Current: 356/445
• CPC Class Codes: G01N 21/11 Filling or emptying of cuvettes
• CPC Class Codes: G01N 21/552 Attenuated total reflection
• CPC Class Codes: G01N 21/648 using evanescent coupling or surface plasmon coupling for the excitation of fluorescence

Abstract

A method and a microelectronic sensor device for making optical examinations in an investigation region at the contact surface of a carrier, wherein an input light beam is sent from a light source towards the investigation region, and wherein an output light beam coming from the investigation region is detected by a light detector. An evaluation unit that is coupled to the light detector is adapted to determine the wetting grade of the investigation region based on a characteristic parameter of the output light beam. The evaluation unit may be adapted to determine a change in the light intensity caused by a liquid contacting the contact surface. The wetting grade may be detected in a test region that is located adjacent to the investigation region and that has a higher roughness than the investigation region.

Claims

1. A microelectronic sensor device for optical examinations in an investigation region of a carrier, the microelectronic sensor device comprising

a light source for emitting an input light beam;

a contact surface for receiving the input light beam and reflecting an output light beam;

a light detector for determining a characteristic parameter of the output light beam reflected from the contact surface;

an evaluation unit for when the characteristic parameter indicates wetness, detecting a wetting grade of the investigation region based on the characteristic parameter, the wetting grade indicating an amount of the contact surface by a fluid.

2. The microelectronic sensor device according to claim 1, wherein the characteristic parameter comprises the amount of light of the output light beam.

3. The microelectronic sensor device according to claim 1, wherein the evaluation unit is adapted to determine and compare the characteristic parameters before and after the fluid has been applied to the contact surface.

4. The microelectronic sensor device according to claim 1, wherein the evaluation unit is adapted to process a triggering signal from a fluid controller that controls the application of the fluid to the contact surface.

5. The microelectronic sensor device according to claim 1, wherein the evaluation unit is adapted to determine and compare the characteristic parameters before and after a carrier is placed into the reach of the input light beam.

6. The microelectronic sensor devise according to claim 1, wherein the light source comprises a beam regulator for at least temporarily emitting an input light beam into the surroundings of the investigation region.

7. The microelectronic sensor device according to claim 1, comprising a scanning unit for moving a single light beam, a switching unit for switching between at least two light beams, and/or a collimator unit for changing the width of the input light beam.

8. The microelectronic sensor device according to claim 1, wherein the light detector comprises a plurality of different sensor units associated to different components of the output light beam.

9. The microelectronic sensor device according to claim 1, comprising a signaling unit for indicating the wetting grade, particularly an insufficient wetting, of the investigation region.

10. The microelectronic sensor device according to claim 1, comprising a wetting regulator, particularly an ultrasonic vibrator, for adjusting the wetting of the investigation region.

11. The microelectronic sensor device according to claim 1, comprising an operation controller for controlling the light source and/or the light detector in dependence on the detection result of the evaluation unit.

12. The microelectronic sensor device according to claim 1, wherein the operation controller is adapted to initiate an optical examination in the investigation region after a predetermined wetting grade has been detected.

13. The microelectronic sensor device according to claim 1, comprising a carrier having a contact surface with an investigation region, wherein said contact surface has at least locally a roughness of more than about 100 nm.

14. The microelectronic sensor device according to claim 1, further comprising a carrier having a contact surface with an investigation region, wherein the contact surface has a higher roughness in a test region near the investigation region than in the investigation region.

16. The microelectronic sensor device according to claim 1, wherein the device is configured for at least one of molecular diagnostics, biological sample analysis, and chemical sample analysis.

15. A method for making optical examinations in an investigation region at the contact surface of a carrier, the method comprising acts of:

emitting an input light beam towards the contact surface;

determining a characteristic parameter of an output light beam that comes from the contact surface;

detecting a wetting grade of the investigation region based on the characteristic parameter when the characteristic parameter indicates wetness, the wetting grade indicating an amount of the contact surface contacted by a fluid.