Hepatic electrical stimulation

• US 8,412,319 B2
• Filed: 01/13/2011
• Issued: 04/02/2013
• Est. Priority Date: 06/14/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Pasricha, Pankaj J., Chen, Jiande
• Primary Examiner(s): Layno, Carl H
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/005,535
• Publication Number:
  US 20110118812A1
• Time in Patent Office: 810 Days
• Field of Search: 607/2, 607/116
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.

Claims

1. A method of electrical stimulation of liver visceral fat of a subject having a liver, said method comprising:

positioning one or more stimulatory electrodes in or on the liver visceral fat of the subject; and

providing electrical stimulation to the liver visceral fat of the subject.

2. The method of claim 1, wherein the electrical stimulation is provided for a period of up to about 180 minutes.

3. The method of claim 2, wherein the electrical stimulation is provided at a frequency ranging from about 5 Hz to about 500 Hz.

4. The method of claim 3, wherein the electrical stimulation is provided as a series of pulses, wherein each pulse is provided for about 0.1 ms to about 2 ms.

5. The method of claim 1, wherein the stimulation is long pulse electrical stimulation.

6. The method of claim 1, wherein the stimulation is short pulse electrical stimulation.

7. The method of claim 1, wherein the stimulation is a combination of long pulse and short pulse electrical stimulation.

8. The method of claim 1, wherein the stimulation is a train of pulses.

9. The method of claim 8, wherein the pulses have a width of about 0.1 to about 2 MS.

10. The method of claim 8, wherein the pulses have a frequency from about 1 to about 30 Hz.

11. The method of claim 8, wherein the pulses have an amplitude from about 0.1 to about 20 mA.

12. A method of reducing one or more risk factors of metabolic syndrome in a subject, wherein said subject has a liver and one or more risk factors of metabolic syndrome, said method comprising:

carrying out the method of claim 1 under conditions effective to reduce one or more risk factors of metabolic syndrome.

13. The method of claim 12, wherein the one or more risk factors of metabolic syndrome are glucose levels more than about 110 mg/dL, obesity, insulin resistance, levels of serum triglycerides more than about 150 mg/dL, serum HDL cholesterol levels less than about 50 mg/dL, or blood pressure levels more than about 130/85 mmHg.

14. The method of claim 12, wherein the electrical stimulation is provided for a period of up to about 180 minutes.

15. The method of claim 12, wherein the electrical stimulation is provided at a frequency ranging from about 5 Hz to about 500 Hz.

16. The method of claim 12, wherein the electrical stimulation is provided as a series of pulses, wherein each pulse is from about 0.1 ms to about 2 ms.

17. The method of claim 12, wherein the one or more risk factors is a glucose level more than about 110 mg/dL.

18. The method of claim 17, wherein the glucose level is reduced to less than about 100 mg/dL.

19. A method of treating diabetes in a subject, said method comprising:

carrying out the method of claim 1 under conditions effective to reduce a glucose level of the subject, wherein the glucose level of the subject is more than about 110 mg/dL.

20. A method of treating coronary heart disease in a subject, said method comprising:

carrying out the method of claim 1 under conditions effective to reduce a glucose level of the subject, wherein the glucose level if the subject is more than about 100 mg/mL.

21. A method of treating a subject with an eating disorder, said method comprising:

carrying out the method of claim 1 under conditions effective to increase weight loss in the subject.

22. A method of placing a visceral fat stimulatory device on a surface of or into visceral fat of the liver of a subject, wherein the placement occurs from the exterior of the subject, said method comprising:

inserting an end of a needle with an interior bore from the exterior of the subject to the surface of or into the visceral fat of the liver of the subject;

inserting the device through the interior bore of the needle until the device engages at least the surface of the visceral fat of the liver; and

removing the needle, wherein the device is placed on the surface of or into the visceral fat of the liver, wherein the device is an electrode.