Rest phase heart pacing

• US 8,412,323 B2
• Filed: 01/23/2009
• Issued: 04/02/2013
• Est. Priority Date: 01/29/2008
• Status: Active Grant

• Current Assignee: Inovise Medical, Inc.
• Original Assignee: Inovise Medical, Inc.
• Inventors: Bauer, Peter T.
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US12/321,647
• Publication Number:
  US 20090204165A1
• Time in Patent Office: 1,530 Days
• Field of Search: 607/9, 607/17, 600/509, 600/514, 600/528
• US Class Current: 607/9
• CPC Class Codes: A61N 1/36578 controlled by mechanical motion of the heart wall, e.g. measured by an accelerometer or microphone
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters

Abstract

A computer method, employable during an at-rest period of a pacemaker patient, for controlling the operation of the pacemaker so as maximally to support the patient'"'"'s hemodynamic behavior in a context involving inhibiting fluid overload. The method involves (a) collecting simultaneously occurring ECG and heart-sound information, (b) processing the collected information to obtain at least S3 data, and in certain instances also EMAT and/or % LVST data, (c) utilizing such obtained data, and during the at-rest period, applying (a) pacing rate, (b) pacing intensity, (c) atrio-ventricular delay, and (d) inter-ventricular delay control to the pacemaker. Processing involves (a) calculating from the obtained data an actual, real-time, acoustic cardiographic therapy (AC) value which is to be employed in relation to controlling pacemaker activity, and (b) comparing the actual AC value to a pre-established, related, rest-period-associated, reference AC value to detect differences therebetween, with the utilizing and applying steps being implemented so as to minimize such differences.

Claims

1. An at-rest-dedicated, acoustic-cardiography method, utilizing the technique of at-rest, real-time, computer-monitored-and-performed difference minimizing between actual real-time, and available-reference, AC (acoustic cardiographic) values that are based upon at-rest-patient-relevant, acquired and computer-processed heart-sound and/or ECG data involving a pacemaker patient having heart failure and being at risk for fluid overload, for adjusting and controlling the patient'"'"'s pacemaker'"'"'s operational (a) pacing rate, (b) pacing intensity, (c) atrio-ventricular delay, and (d) inter-ventricular delay so as to effect pacing in a manner maximally supporting the patient'"'"'s hemodynamic behavior in a context involving inhibiting real-time at-rest fluid overload, said method comprising

collecting in a continuum, solely during an at-rest period of the subject pacemaker patient, simultaneously occurring ECG and heart-sound continuum information,

obtaining, for computer processing, from the collected continuum information at least S3 heart-sound data,

utilizing the obtained data, and employing at least data averaging, calculating an actual, real-time, acoustic cardiographic (AC) value,

comparing in real time the calculated, actual, real-time AC value to a pre-established, related, at-rest-period-associated, available reference AC value to detect differences therebetween,

during the mentioned at-rest period, and in the associated real time, appropriately applying, to the operation of the pacemaker, adjustment-based change control over at least one of the pacemaker'"'"'s operational (a) pacing rate, (b) pacing intensity, (c) atrio-ventricular delay, and (d) inter-ventricular delay so as to minimize the detected AC-value differences, and

by said applying, effecting pacing by the pacemaker in a manner maximally supporting the patient'"'"'s hemodynamic behavior through inhibiting fluid overload.

2. The method of claim 1, wherein said obtaining of data further includes obtaining at least one of EMAT and % LVST data.