Neurostimulator involving stimulation strategies and process for using it

• US 8,412,333 B2
• Filed: 05/12/2011
• Issued: 04/02/2013
• Est. Priority Date: 04/05/2000
• Status: Expired due to Fees

• Current Assignee: Neuropace Inc.
• Original Assignee: Neuropace Inc.
• Inventors: Pless, Benjamin D
• Primary Examiner(s): Lavert, Nicole F
• Application Number:
  US13/106,747
• Publication Number:
  US 20110213442A1
• Time in Patent Office: 691 Days
• Field of Search: 607/45, 607/62, 607/72, 600/544
• US Class Current: 607/45
• CPC Class Codes: A61N 1/36064 Epilepsy
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36135 using physiological parameters
• CPC Class Codes: A61N 1/36178 Burst or pulse train parameters

Abstract

This is a neurostimulator that is configured to treat epilepsy and other neurological disorders using certain stimulation strategies, particularly changing various pulse parameters, during the imposition of a burst of those pulses. The invention includes the processes embodying those stimulation strategies.

Claims

1. A method for treating an abnormal neurological condition comprising:

detecting electrical activity of brain tissue wherein the detected electrical activity is characterized by at least one detected parameter;

applying a plurality of bursts of electrical stimulation to the brain tissue, wherein each burst of the plurality of bursts comprises a determined number of electrical pulses being characterizable by a plurality of burst parameters; and

varying at least one of the burst parameters during at least a portion of the time the plurality of bursts of electrical stimulation is applied to vary the bursts so that the burst parameters of at least one burst of the plurality of bursts are different from the burst parameters of at least one other burst of the plurality of bursts, wherein the varying is based on a timing of the at least one detected parameter.

2. The method of claim 1 further including varying at least one of the burst parameters based on the timing of the at least one detected parameter relative to a timing of an application of the at least one burst of the plurality of bursts.

3. The method of claim 1 wherein the at least one detected parameter is a pulse-to-pulse interval and the method further includes varying at least one of the burst parameters of the plurality of burst parameters based on the detected pulse-to-pulse interval.

4. A method for treating an abnormal neurological condition comprising:

detecting electrical activity of brain tissue wherein the detected electrical activity is characterized by at least one detected parameter;

applying a plurality of bursts of electrical stimulation to the brain tissue, wherein each burst of the plurality of bursts comprises a determined number of electrical pulses being characterizable by a plurality of burst parameters and at least one burst of the plurality of bursts is applied at a time that is synchronized to a time at which the at least one detected parameter is detected; and

varying at least one of the burst parameters during at least a portion of the time the plurality of burst parameters of electrical stimulation is applied to vary the bursts so that the burst parameters of at least one burst of the plurality of bursts are different from the burst parameters of at least one other burst of the plurality of bursts.

5. A method for treating an abnormal neurological condition comprising:

detecting a rate of electrical activity in signals sensed from brain tissue;

identifying an interval corresponding to the detected rate;

applying a plurality of bursts of electrical stimulation to the brain tissue, wherein each burst of the plurality of bursts comprises a determined number of electrical pulses being characterizable by a plurality of burst parameters and at least one burst of the plurality of bursts is applied based on detection of the interval; and

varying at least one of the burst parameters during at least a portion of a time the plurality of bursts of electrical stimulation is applied to vary the bursts so that the burst parameters of at least one burst of the plurality of bursts are different from the burst parameters of at least one other burst of the plurality of bursts.