Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
First Claim
1. A method of optimizing the position of an electrode relative to a subject'"'"'s inflammatory reflex, the method comprising:
- implanting an electrode in electrical communication with either the vagus nerve, the splenic nerve, the hepatic nerve or the trigeminal nerve so the electrode can be stimulated to inhibit inflammation;
applying an electrical stimulus to electrode;
detecting a stimulation artifact;
determining an indicator of the power of the stimulation artifact, wherein the step of determining an indicator of the power of the stimulation artifact includes calculating the power of the stimulation artifact and a second stimulation artifact; and
adjusting the position of the stimulation electrode based on the indicator of the power of the stimulation artifact.
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Accused Products
Abstract
Described herein are methods, devices and system for selecting an optimum position of a stimulation electrode, and particularly methods, devices and systems for optimizing the position of a stimulation electrode for stimulating the inflammatory reflex and thereby inhibiting inflammation. The methods, devices and systems described herein may generally include the analysis of one or more artifact modalities arising after the application of a stimulation pulse. One or more of these artifact modalities (e.g., EMG, ECG, etc.) may be detected and used to generate a comparable indicator of the fitness of the position of the electrode relative to a target, such as a portion of the inflammatory reflex like the vagus nerve.
567 Citations
18 Claims
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1. A method of optimizing the position of an electrode relative to a subject'"'"'s inflammatory reflex, the method comprising:
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implanting an electrode in electrical communication with either the vagus nerve, the splenic nerve, the hepatic nerve or the trigeminal nerve so the electrode can be stimulated to inhibit inflammation; applying an electrical stimulus to electrode; detecting a stimulation artifact; determining an indicator of the power of the stimulation artifact, wherein the step of determining an indicator of the power of the stimulation artifact includes calculating the power of the stimulation artifact and a second stimulation artifact; and adjusting the position of the stimulation electrode based on the indicator of the power of the stimulation artifact. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method of optimizing the position of an electrode relative to a subject'"'"'s inflammatory reflex, the method comprising:
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implanting an electrode in electrical communication with either the vagus nerve, the splenic nerve, the hepatic nerve or the trigeminal nerve so the electrode can be stimulated to inhibit inflammation; applying an electrical stimulus to electrode; detecting a stimulation artifact; determining an indicator of the power of the stimulation artifact; adjusting the position of the stimulation electrode based on the indicator of the power of the stimulation artifact; and repeating the steps of applying an electrical stimulus to the electrode and detecting the stimulation artifact;
further wherein the step of determining the indicator of the power of the stimulation artifact comprises averaging the detected stimulation artifacts to determine the indicator of the power of the stimulation artifact.
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Specification