Fabrication of multi-sensor arrays
First Claim
1. A method of making an analyte sensor apparatus for implantation within a mammal comprising the steps of:
- providing a substrate layer;
forming a plurality of analyte sensor elements on the substrate layer including a first analyte sensor element and a second analyte sensor element, wherein each of the analyte sensor elements is adapted to contact and sense analyte and comprise;
at least three working electrodes disposed on the substrate layer;
a glucose oxidase layer disposed upon the at least three working electrodes;
an analyte modulating layer disposed on the glucose oxidase layer, wherein the analyte modulating layer comprises a hydrogel composition;
an adhesion promoting layer disposed between the glucose oxidase layer and the analyte modulating layer that functions to promote adhesion between the glucose oxidase layer and the analyte modulating layer, wherein the adhesion promoting layer comprises a compound having a siloxane moiety and;
forming a lid layer upon at least one of the plurality of analyte sensor elements;
forming a sealed aperture on the lid layer;
forming at least one analyte sensor membrane disposed upon at least one of the plurality of analyte sensor elements in a manner that can reversibly prevent an analyte from contacting the at least one of the plurality of analyte sensor elements, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and
forming at least one structure operatively coupled to the analyte sensing apparatus for relaying information to and away from the analyte sensing apparatus, wherein the analyte sensing device is made so that the first and second analyte sensor elements in the analyte sensing device sense different analytes, so that an analyte sensor apparatus is made.
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Accused Products
Abstract
The disclosure provides methods for fabricating a long-term analyte sensor for measuring at least one analyte in the body of a user. The analyte sensors made by these methods include a plurality of analyte contacting sensor elements and at least one structure for relaying information to and from the sensor. The analyte sensor so fabricated further includes at least one sensor protection membrane that is controllable in a manner such that sensor elements may be activated (e.g. exposed to the external environment) at different times so as to extend the useful life of the sensor. In illustrative analyte sensors, the analyte is glucose.
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Citations
11 Claims
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1. A method of making an analyte sensor apparatus for implantation within a mammal comprising the steps of:
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providing a substrate layer; forming a plurality of analyte sensor elements on the substrate layer including a first analyte sensor element and a second analyte sensor element, wherein each of the analyte sensor elements is adapted to contact and sense analyte and comprise; at least three working electrodes disposed on the substrate layer; a glucose oxidase layer disposed upon the at least three working electrodes; an analyte modulating layer disposed on the glucose oxidase layer, wherein the analyte modulating layer comprises a hydrogel composition; an adhesion promoting layer disposed between the glucose oxidase layer and the analyte modulating layer that functions to promote adhesion between the glucose oxidase layer and the analyte modulating layer, wherein the adhesion promoting layer comprises a compound having a siloxane moiety and; forming a lid layer upon at least one of the plurality of analyte sensor elements; forming a sealed aperture on the lid layer; forming at least one analyte sensor membrane disposed upon at least one of the plurality of analyte sensor elements in a manner that can reversibly prevent an analyte from contacting the at least one of the plurality of analyte sensor elements, wherein the permeability of the analyte sensor membrane can be controlled to allow an analyte to contact at least one of the plurality of analyte sensor elements; and forming at least one structure operatively coupled to the analyte sensing apparatus for relaying information to and away from the analyte sensing apparatus, wherein the analyte sensing device is made so that the first and second analyte sensor elements in the analyte sensing device sense different analytes, so that an analyte sensor apparatus is made. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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Specification