Systems, devices, and methods including infection-fighting and monitoring shunts
First Claim
Patent Images
1. An implantable shunt system, comprising:
- a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways configured to receive a cerebrospinal fluid of a biological subject;
one or more energy emitters configured to emit an energy stimulus to one or more regions proximate at least one of the outer surface and the inner surface of the body structure, the energy stimulus of a character and for a duration sufficient to induce programmed cell death without substantially inducing necrosis of at least a portion of cells proximate at least one of the outer surface and the inner surface of the body structure; and
a sensor component in optical communication along an optical path with at least one of the one or more energy emitters;
wherein the sensor component includes a biological molecule capture layer having an array of different binding molecules that specifically bind one or more target molecules.
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Accused Products
Abstract
Systems, devices, methods, and compositions are described for providing an actively controllable shunt configured to, for example, monitor, treat, or prevent an infection.
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Citations
18 Claims
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1. An implantable shunt system, comprising:
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a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways configured to receive a cerebrospinal fluid of a biological subject; one or more energy emitters configured to emit an energy stimulus to one or more regions proximate at least one of the outer surface and the inner surface of the body structure, the energy stimulus of a character and for a duration sufficient to induce programmed cell death without substantially inducing necrosis of at least a portion of cells proximate at least one of the outer surface and the inner surface of the body structure; and a sensor component in optical communication along an optical path with at least one of the one or more energy emitters; wherein the sensor component includes a biological molecule capture layer having an array of different binding molecules that specifically bind one or more target molecules. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An implantable shunt system, comprising:
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a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways configured to receive a cerebrospinal fluid of a biological subject; one or more energy emitters configured to emit an energy stimulus to one or more regions proximate at least one of the outer surface and the inner surface of the body structure, the energy stimulus of a character and for a duration sufficient to induce programmed cell death without substantially inducing necrosis of at least a portion of cells proximate at least one of the outer surface and the inner surface of the body structure; and a sensor component in optical communication along an optical path with at least one of the one or more energy emitters; wherein the sensor component includes one or more sensors configured to detect at least one characteristic associated with the cerebrospinal fluid of the biological subject; wherein the at least one characteristic associated with the cerebrospinal fluid includes at least one of a psychotic disorder indication parameter, a psychotic state indication parameter, a psychotic trait indication parameter, a psychosis indication parameter, and a predisposition for a psychosis indication parameter.
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12. An implantable shunt system, comprising:
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a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways configured to receive a cerebrospinal fluid of a biological subject; one or more energy emitters configured to emit an energy stimulus to one or more regions proximate at least one of the outer surface and the inner surface of the body structure, the energy stimulus of a character and for a duration sufficient to induce programmed cell death without substantially inducing necrosis of at least a portion of cells proximate at least one of the outer surface and the inner surface of the body structure; a sensor component in optical communication along an optical path with at least one of the one or more energy emitters; and one or more processors configured to perform a comparison of the at least one characteristic associated with the cerebrospinal fluid to stored reference data, and to generate a response based at least in part on the comparison; wherein the sensor component includes one or more sensors configured to detect at least one characteristic associated with the cerebrospinal fluid of the biological subject. - View Dependent Claims (13)
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14. An implantable shunt system, comprising:
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a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways configured to receive a cerebrospinal fluid of a biological subject; one or more energy emitters configured to emit an energy stimulus to one or more regions proximate at least one of the outer surface and the inner surface of the body structure, the energy stimulus of a character and for a duration sufficient to induce programmed cell death without substantially inducing necrosis of at least a portion of cells proximate at least one of the outer surface and the inner surface of the body structure; and a sensor component in optical communication along an optical path with at least one of the one or more energy emitters; wherein the sensor component includes one or more refractive index sensors.
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15. An implantable shunt system, comprising:
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a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways configured to receive a cerebrospinal fluid of a biological subject; one or more energy emitters configured to emit an energy stimulus to one or more regions proximate at least one of the outer surface and the inner surface of the body structure, the energy stimulus of a character and for a duration sufficient to induce programmed cell death without substantially inducing necrosis of at least a portion of cells proximate at least one of the outer surface and the inner surface of the body structure; and a sensor component in optical communication along an optical path with at least one of the one or more energy emitters; wherein the sensor component includes one or more surface plasmon resonance sensors.
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16. A method, comprising:
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providing an energy stimulus to an interior of one or more fluid-flow passageways of an in vivo implanted cerebrospinal fluid management device in response to a change in an optical parameter associated with a cerebrospinal fluid received within the at least one fluid-flow passageway; wherein providing the energy stimulus to the interior of the one or more fluid-flow passageways of an in vivo implanted cerebrospinal fluid management device includes providing an energy stimulus to an interior of one or more fluid-flow passageways of an in vivo implanted cerebrospinal fluid management device in response to a change in a refractive index parameter associated with a cerebrospinal fluid received within the at least one fluid-flow passageway. - View Dependent Claims (17, 18)
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Specification