Device and method for ablation of cardiac tissue

• US 8,414,573 B2
• Filed: 10/11/2006
• Issued: 04/09/2013
• Est. Priority Date: 05/16/2002
• Status: Expired due to Fees

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Francischelli, David E.
• Primary Examiner(s): Dvorak, Linda
• Assistant Examiner(s): SCOTT, AMANDA L
• Application Number:
  US11/545,829
• Publication Number:
  US 20070032786A1
• Time in Patent Office: 2,372 Days
• Field of Search: 606/41, 606 45- 50, 607101-105
• US Class Current: 606/41
• CPC Class Codes: A61B 18/1402 Probes for open surgery
• CPC Class Codes: A61B 2018/00809 measured thermochromatically
• CPC Class Codes: A61B 2018/1472 for use with liquid electrolyte, e.g. virtual electrodes

Abstract

Methods for delivering precise amounts of fluid into cardiac tissue for the purpose of facilitating ablation of the tissue along a desired lesion line. One method injects fluid through a hollow needle. The injected fluid can be a highly conductive fluid injected in conjunction with radiofrequency ablation to create an ablative virtual electrode. The injected conductive fluid can provide deeper and narrower conduction paths and resulting lesions. Radiofrequency ablation can be performed at the same time as the fluid injection, using the injection device as an electrode, or subsequent to the fluid injection, using a separate device. In some methods, the injected fluid is a protective fluid, injected to protect tissue adjacent to the desired lesion line. Fluid delivery can be endocardial, epicardial, and epicardial on a beating heart. The present methods find one use in performing maze procedures to treat atrial fibrillation.

Claims

1. A method for ablation of myocardial tissue defining opposing surfaces separated by a thickness, the method comprising:

providing a hand-held instrument having a hollow needle;

selecting one of the opposing surfaces for penetration by the needle;

selecting a desired line of ablation on the selected surface of the myocardial tissue;

applying the needle to the tissue at a portion of the desired line of ablation such that it penetrates the selected surface and into the thickness;

delivering a predetermined amount of fluid into the penetrated tissue to facilitate ablation of the tissue along the desired lesion line; and

applying radiofrequency ablation through the needle.

2. A method according to claim 1 wherein the needle delivers a conductive liquid.

3. A method according to claim 2 wherein the conductive liquid is a saline solution that creates an ablative virtual electrode when delivered in combination with the application of radiofrequency ablation.

4. A method according to claim 1 wherein the needle is moved relative to the selected surface along the desired lesion line as the needle is advanced into and retracted from the tissue.

5. A method according to claim 4 wherein the liquid and the ablative radiofrequency energy are synchronized to form a virtual electrode and ablate the tissue along the desired lesion line.

6. A method according to claim 1 also comprising completing delivery of fluid along the desired lesion line and subsequently applying to the desired lesion line radiofrequency ablation.

7. A method according to claim 6 wherein the fluid is a hypertonic saline solution.

8. A method according to claim 1 wherein the fluid is a protective fluid which increases the electrical impedance of the myocardial tissue.

9. A method according to claim 8 wherein the protective fluid is delivered to tissue near a heart valve.

10. A method according to claim 8 wherein the protective fluid is delivered to tissue near a blood vessel.

11. A method according to claim 8 wherein the fluid is a hypotonic fluid.

12. A method according to claim 1, wherein the fluid comprises an electrically conductive liquid mixed with a viscosity enhancing agent.

13. A method according to claim 1, wherein the provided hand-held instrument further comprises a needle array comprising a plurality of hollow needles in addition to the hollow needle, where in the applying includes applying the plurality of needles to penetrate the tissue, wherein the delivering includes delivering electrically conductive fluid into the penetrated tissue through two of the plurality of needles.

14. A method according to claim 1, wherein the step of applying the needle includes:

advancing the needle through the selected surface and into the thickness; and

retracting the needle from the thickness and back through the selected surface;

wherein the steps of advancing and retracting include moving the needle through a linear travel path.

15. A method according to claim 14, wherein the hand-held instrument includes a needle housing forming an opening through which the needle reciprocates, and further wherein the steps of advancing and retracting include subjecting the needle to a linear reciprocating movement relative to the needle housing.

16. A method for ablation of myocardial tissue comprising:

providing a hand-held instrument having an injection port for injecting fluid into myocardial tissue;

selecting a desired linear line of ablation on a surface of the myocardial tissue;

applying the injection port through the surface and into the tissue at a portion of the desired line of ablation;

delivering a predetermined amount of fluid into the myocardial tissue to facilitate ablation of the tissue along the desired lesion line; and

applying radiofrequency ablation through the injection device.

17. A method according to claim 16 wherein the injection device delivers a conductive liquid.

18. A method according to claim 17 wherein the conductive liquid is a saline solution that creates an ablative virtual electrode when delivered in combination with the application of radiofrequency ablation.

19. A method according to claim 16 wherein the injection port is moved along the desired lesion line on the tissue as the fluid is injected into the tissue.

20. A method according to claim 19 wherein the liquid and the ablative radiofrequency energy are synchronized to form a virtual electrode and ablate the tissue along the desired lesion line.

21. A method according to claim 16 also comprising completing delivery of fluid along the desired lesion line and subsequently applying to the desired lesion line radiofrequency ablation.

22. A method according to claim 21 wherein the fluid is a hypertonic saline solution.

23. A method according to claim 21 wherein the fluid is a protective fluid which increases the electrical impedance of the myocardial tissue.

24. A method according to claim 23 wherein the protective fluid is delivered to tissue near a heart valve.

25. A method according to claim 23 wherein the protective fluid is delivered to tissue near a blood vessel.

26. A method according to claim 23 wherein the fluid is a hypotonic fluid.

27. A method according to claim 16, wherein the fluid comprises a viscosity enhancing agent.