Biodegradable stent of a polyorthoester polymer or a polyanhydride polymer

• US 8,414,642 B2
• Filed: 12/01/2008
• Issued: 04/09/2013
• Est. Priority Date: 04/13/2000
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated
• Original Assignee: Advanced Cardiovascular Systems Incorporated
• Inventors: Dutta, Debashis
• Primary Examiner(s): Nguyen, Victor
• Application Number:
  US12/325,979
• Publication Number:
  US 20090082853A1
• Time in Patent Office: 1,590 Days
• Field of Search: 623 112- 113, 623/1.15, 623/1.38, 623 142- 144, 623/1.46, 424/426, 424/484, 427/2.25
• US Class Current: 623/1.46
• CPC Class Codes: A61F 2/86 Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

A stent is fabricated utilizing a polymer that is selected for its tendency to degrade from the surface inwardly rather than undergo bulk erosion so as to substantially reduce the risk of large particles becoming detached and being swept downstream. Such polymer is hydrophobic yet has water-labile linkages interconnecting the monomers. Ester or imide bonds are incorporated in the polymer to render the surface degrading materials suitable for use in stent applications. The stent may be coated with such polymer or may be wholly formed therefrom.

Claims

1. A stent wholly constructed of a biodegradable polymer that degrades from its surface inwardly when subjected to blood flow, such that bulk erosion is effectively precluded;

wherein said polymer is hydrophobic and has water-labile linkages connecting monomers;

wherein said polymer comprises a polyorthoester or a polyanhydride; and

wherein said polyorthoester polymer or said polyanhydride polymer incorporates imide bonds, and wherein said polyorthoester polymer or said polyanhydride polymer comprises an imide content of 20% to 40% of said polymer.

2. The stent of claim 1, wherein said polymer comprises a polyanhydride.

3. The stent of claim 2, wherein said polymer incorporates ester bonds.

4. The stent of claim 1, wherein said polymer comprises a polyorthoester.

5. The stent of claim 4, wherein said polymer incorporates ester bonds.

6. The stent of claim 1, wherein said polymer is loaded with a pharmacological agent.

7. The stent of claim 6, wherein said pharmacological agent comprises heparin.