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Subcutaneous glucose electrode

  • US 8,414,750 B2
  • Filed: 09/29/2010
  • Issued: 04/09/2013
  • Est. Priority Date: 03/04/1991
  • Status: Expired due to Fees
First Claim
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1. A glucose sensor comprising:

  • a working electrode; and

    a multilayer membrane complex comprising;

    an analyte responsive sensing layer disposed on top and in electrical contact with the working electrode, the analyte responsive sensing layer comprising a glucose-specific enzyme, a mediator and a first polymer selected from the group consisting of poly(vinylimidazole) and poly(vinyl pyridine), wherein at least one of the glucose-specific enzyme and the mediator is chemically bonded to the first polymer; and

    a diffusion-limiting layer comprising a crosslinked second polymer disposed on top and in contact with the analyte responsive sensing layer.

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