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Drug releasing coatings for medical devices

  • US 8,414,909 B2
  • Filed: 11/19/2007
  • Issued: 04/09/2013
  • Est. Priority Date: 11/20/2006
  • Status: Active Grant
First Claim
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1. A balloon catheter for delivering a therapeutic agent to a target site of a blood vessel, the balloon catheter comprising:

  • an inflatable polyamide balloon; and

    a coating layer that adheres to an exterior surface of the inflatable polyamide balloon,wherein;

    the coating layer comprises a hydrophobic therapeutic agent and at least one water-soluble additive;

    the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, and combinations thereof;

    the at least one water-soluble additive comprises a PEG fatty ester selected from the group consisting of PEG laurates, PEG oleates, PEG stearates, PEG glyceryl laurates, PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan monolaurates, PEG sorbitan monooleates, PEG sorbitan stearates, PEG sorbitan laurates, PEG sorbitan oleates, and PEG sorbitan palmitates; and

    the coating layer does not include an iodine covalent bonded contrast agent.

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