Drug releasing coatings for medical devices
First Claim
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1. A balloon catheter for delivering a therapeutic agent to a target site of a blood vessel, the balloon catheter comprising:
- an inflatable polyamide balloon; and
a coating layer that adheres to an exterior surface of the inflatable polyamide balloon,wherein;
the coating layer comprises a hydrophobic therapeutic agent and at least one water-soluble additive;
the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, and combinations thereof;
the at least one water-soluble additive comprises a PEG fatty ester selected from the group consisting of PEG laurates, PEG oleates, PEG stearates, PEG glyceryl laurates, PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan monolaurates, PEG sorbitan monooleates, PEG sorbitan stearates, PEG sorbitan laurates, PEG sorbitan oleates, and PEG sorbitan palmitates; and
the coating layer does not include an iodine covalent bonded contrast agent.
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Abstract
The invention relates to a medical device for delivering a therapeutic agent to a tissue. The medical device has a layer overlying the exterior surface of the medical device. The layer contains a therapeutic agent and an additive. The additive has a hydrophilic part and a hydrophobic part and the therapeutic agent is not enclosed in micelles or encapsulated in particles or controlled release carriers.
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Citations
20 Claims
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1. A balloon catheter for delivering a therapeutic agent to a target site of a blood vessel, the balloon catheter comprising:
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an inflatable polyamide balloon; and a coating layer that adheres to an exterior surface of the inflatable polyamide balloon, wherein; the coating layer comprises a hydrophobic therapeutic agent and at least one water-soluble additive; the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, rapamycin, and combinations thereof; the at least one water-soluble additive comprises a PEG fatty ester selected from the group consisting of PEG laurates, PEG oleates, PEG stearates, PEG glyceryl laurates, PEG glyceryl oleates, PEG glyceryl stearates, PEG sorbitan monolaurates, PEG sorbitan monooleates, PEG sorbitan stearates, PEG sorbitan laurates, PEG sorbitan oleates, and PEG sorbitan palmitates; and the coating layer does not include an iodine covalent bonded contrast agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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Specification