Cross-linked polymer particles

• US 8,414,927 B2
• Filed: 09/17/2007
• Issued: 04/09/2013
• Est. Priority Date: 11/03/2006
• Status: Active Grant

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Richard, Robert E.
• Primary Examiner(s): Krass, Frederick
• Assistant Examiner(s): Shomer, Isaac
• Application Number:
  US11/856,237
• Publication Number:
  US 20080226741A1
• Time in Patent Office: 2,031 Days
• Field of Search: None
• US Class Current: 424/501
• CPC Class Codes: A61F 6/14 intra-uterine type
• CPC Class Codes: A61K 31/4192 1,2,3-Triazoles
• CPC Class Codes: A61K 47/32 Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers , poly(meth)acrylates, or polyvinyl pyrrolidone
• CPC Class Codes: A61K 47/34 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers A61K47/10 takes precedence
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0034 Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61K 9/167 with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface with further drug-free outer coating A61K9/5073
• CPC Class Codes: A61K 9/1676 having a drug-free core with discrete complete coating layer containing drug adsorbates of liquid drug formulations on inert powders without simultaneous granulation step A61K9/141; with further drug-free outer coating A61K9/5078; drug conjugated to non-active particles A61K47/6921
• CPC Class Codes: A61K 9/5031 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
• CPC Class Codes: A61K 9/5036 Polysaccharides, e.g. gums, alginate; Cyclodextrin
• CPC Class Codes: A61K 9/5057 Gelatin
• CPC Class Codes: A61K 9/5073 having two or more different coatings optionally including drug-containing subcoatings
• CPC Class Codes: A61K 9/5078 with drug-free core
• CPC Class Codes: B32B 5/16 characterised by features of a layer formed of particles, e.g. chips, powder or granules layer formed of natural mineral particles B32B19/00; layer being formed of wood fibres, chips or particles B32B21/02
• CPC Class Codes: C08J 2201/024 Preparation or use of a blowing agent concentrate, i.e. masterbatch in a foamable composition
• CPC Class Codes: C08J 2329/04 Polyvinyl alcohol; Partially hydrolysed homopolymers or copolymers of esters of unsaturated alcohols with saturated carboxylic acids
• CPC Class Codes: C08J 3/24 Crosslinking, e.g. vulcanising, of macromolecules mechanical aspects B29C35/00; crosslinking agents C08K
• CPC Class Codes: C08J 9/365 Coating
• CPC Class Codes: Y10T 428/2982 Particulate matter [e.g., sphere, flake, etc.]

Abstract

Biodegradable cross-linked particles, as well as related compositions and methods, are disclosed.

Claims

1. A particle, comprising:

a material comprising a polymer backbone bonded to a chemical species via a 1,2,3-triazole group, wherein the particle has a maximum dimension of at most 5,000 microns and the polymer, backbone comprises polyvinyl alcohol.

2. The particle of claim 1, wherein the chemical species comprises a second polymer backbone.

3. The particle of claim 2, wherein the 1,2,3-triazole group is covalently bonded to the second polymer backbone.

4. The particle of claim 3, wherein the first and second polymer backbones are cross-linked via 1,2,3-triazole group.

5. The particle of claim 1, wherein the 1,2,3-triazole group is biodegradable.

6. The particle of claim 1, wherein the particle has pores.

7. The particle of claim 6, further comprising a therapeutic agent disposed in at least some of the pores of the particle.

8. The particle of claim 1, further comprising a therapeutic agent.

9. The particle of claim 8, wherein the therapeutic agent is covalently bonded to the 1,2,3-triazole group.

10. The particle of claim 1, wherein the first polymer backbone is the same as the second polymer backbone.

11. The particle of claim 1, wherein the first polymer backbone is selected from the group consisting of polyvinyl alcohols, polyHEMAs, carbohydrates, polyethylene oxide/glycols, polyhydroxyethyl acrylates, poly(meth)acrylamides, PLA PGAs, polyacrylic acids, polymethacrylic acids, poly vinyl sulfonates, carboxymethyl celluloses, hydroxyethyl celluloses, polyacrylamides, polyethylene glycols, polyamides, polyureas, polyurethanes, polyesters, polyethers, polystyrenes, polysaccharides, polylactic acids, polyethylenes, polymethylmethacrylates, polycaprolactones, polyglycolic acids, and poly(lacticco-glycolic) acids.

12. A particle, comprising:

a first polymer backbone;

a second polymer backbone; and

a 1,2,3-triazole group,

wherein the 1,2,3-triazole group is covalently bonded to the first and second polymer backbones to cross-link the first and second polymer backbones, and the particle has a maximum dimension of at most 5,000 microns and the first and second polymer backbones comprise polyvinyl alcohol.

13. A composition, comprising:

a carrier fluid; and

a plurality of particles in the carrier fluid,

wherein at least some of the plurality of particles have a maximum dimension of at most 5,000 microns and comprise a material comprising a polymer backbone bonded to a chemical species via a 1,2,3-triazole group and the polymer backbone comprises polyvinyl alcohol.

14. A composition, comprising:

a carrier fluid; and

a plurality of particles in the carrier fluid,

wherein at least some of the plurality of particles have a maximum dimension of at most 5,000 microns and comprise a material comprising a first polymer backbone cross-linked to a second polymer backbone via a 1,2,3-triazole group and the first and second polymer backbones comprise polyvinyl alcohol.

15. A composition, comprising:

a carrier fluid; and

a plurality of particles in the carrier fluid,

wherein at least some of the plurality of particles have a maximum dimension of at most 5,000 microns and comprise;

a polymer backbone;

a chemical species; and

a 1,2,3-triazole group covalently bonded to the polymer backbone and the chemical species

and wherein the polymer backbone comprises polyvinyl alcohol.

16. A composition, comprising:

a carrier fluid; and

a plurality of particles in the carrier fluid,

wherein at least some of the plurality of particles have a maximum dimension of at most 5,000 microns and comprise;

a first polymer backbone;

a second polymer backbone; and

a 1,2,3-triazole group produced covalently bonded to the first and second polymer backbones to cross-link the first and second polymer backbones

and wherein the first and second polymer backbones comprise polyvinyl alcohol.