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Antisense oligomers and methods for inducing immune tolerance and immunosuppression

  • US 8,415,313 B2
  • Filed: 05/11/2006
  • Issued: 04/09/2013
  • Est. Priority Date: 01/23/2004
  • Status: Active Grant
First Claim
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1. A method of inducing increased production of extracellular IL-10 in mature dendritic cells, comprising(a) exposing a population of human dendritic cells that includes mature dendritic cells to an antisense compound composed of phosphorus-containing intersubunit linkages joining a morpholino nitrogen of one subunit to a 5′

  • exocyclic carbon of an adjacent subunit and containing 12-40 subunits, including a base sequence of at least 12 contiguous bases that are complementary to a target region within the sequence identified by SEQ ID NO;

    9, wherein said compound is covalently linked, at one compound end, to an arginine-rich peptide effective to enhance uptake of said compound into the mature dendritic cells, and(b) by said exposing in step (a), blocking expression of full-length CD86 in said cells,(c) by said blocking, thereby producing inhibition of the expression of full-length CD86 on the surface of mature dendritic cells, and enhanced expression of extracellular IL-10 by mature dendritic cells.

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