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Cell-mediated delivery and targeted erosion of noncovalently crosslinked hydrogels

  • US 8,415,325 B2
  • Filed: 06/14/2010
  • Issued: 04/09/2013
  • Est. Priority Date: 03/31/2005
  • Status: Active Grant
First Claim
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1. A method for delivery of a heparin-binding therapeutic compound to a target cell, the method comprising administering in vivo a hydrogel comprising a heparin-binding therapeutic compound capable of receptor-mediated binding to a surface of the target cell;

  • wherein the hydrogel further comprises a cross-linked matrix comprising at least two polymer-LMWH conjugates, wherein the polymer comprises PEG and wherein the polymer of at least one of the polymer-LMWH conjugates is covalently bound to at least one LMWH molecule; and

    wherein a fraction of the polymer-LMWH conjugates is noncovalently bound to the heparin-binding therapeutic compound.

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