Method of differentiating between blood and control solutions containing a common analyte

• US 8,416,398 B2
• Filed: 12/21/2011
• Issued: 04/09/2013
• Est. Priority Date: 12/13/2004
• Status: Expired due to Fees

• Current Assignee: Ascensia Diabetes Care Holdings AG (PHC Holdings Corporation)
• Original Assignee: Bayer Healthcare LLC (Bayer AG)
• Inventors: Marfurt, Karen L.
• Primary Examiner(s): LAUCHMAN, LAYLA G
• Application Number:
  US13/333,008
• Publication Number:
  US 20120149048A1
• Time in Patent Office: 475 Days
• Field of Search: 356/39, 436/44, 422/50
• US Class Current: 356/39
• CPC Class Codes: G01N 1/28 Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Qmounting specimens on microscopic slides G02B21/34; means for supporting the objects or the materials to be analysed in electron microscopes H01J37/20 ; laboratory gas handling apparatus B01L5/00
• CPC Class Codes: G01N 33/66 involving blood sugars, e.g. galactose
• CPC Class Codes: G01N 33/96 involving blood or serum control standard
• CPC Class Codes: Y10T 436/10 Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
• CPC Class Codes: Y10T 436/110833 Utilizing a moving indicator strip or tape
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

Glucose measured in blood samples is distinguished from glucose measured in the control solutions used to test the optical instruments which make such measurements. The control solutions contain a labeling substance recognized by the optical instrument to distinguish glucose measurements made of control solutions from those made of blood samples.

Claims

1. A method of measuring the glucose in blood by an optical instrument, the method comprising the acts of testing the performance of the instrument by adding a control solution containing a known amount of glucose to a test strip adapted to react with the glucose and produce an optical response from an indicator and measuring the response, the control solution contains a labeling substance recognized by the optical instrument and distinguished from the response of the indicator, wherein the labeling substance has a peak absorbance of light that is distinguished from the absorbance of the indicator.

2. The method of claim 1, wherein the labeling substance is indocyanine green.

3. The method of claim 2, wherein the labeling substance is distinguished from a tetrazolium salt indicator.

4. The method of claim 1, wherein the labeling substance has a characteristic response to excitation by a light-emitting diode in the optical instrument that is distinguishable from the response of the indicator.

5. The method of claim 1, further comprising compiling the glucose measurements, the glucose measurements excluding control solution measurements.

6. The method of claim 1, wherein the labeling substance is a dye adapted to be dissolved in the control solution.