Method and device for measuring parameters of cardiac function

• US 8,417,306 B2
• Filed: 02/13/2008
• Issued: 04/09/2013
• Est. Priority Date: 02/16/2007
• Status: Active Grant

• Current Assignee: Mespere LifeSciences Inc.
• Original Assignee: Mespere LifeSciences Inc.
• Inventors: Cheng, Xuefeng
• Primary Examiner(s): LaBalle, Clayton E
• Assistant Examiner(s): REISNER, NOAM S
• Application Number:
  US12/449,146
• Publication Number:
  US 20090326352A1
• Time in Patent Office: 1,882 Days
• Field of Search: 600/324
• US Class Current: 600/324
• CPC Class Codes: A61B 2562/0233 Special features of optical sensors or probes classified in A61B5/00
• CPC Class Codes: A61B 2562/043 in a linear array
• CPC Class Codes: A61B 2562/046 in a matrix array
• CPC Class Codes: A61B 5/0205 Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
• CPC Class Codes: A61B 5/021 Measuring pressure in heart or blood vessels A61B5/0205 takes precedence
• CPC Class Codes: A61B 5/02116 of pulse wave amplitude A61B5/02225 takes precedence
• CPC Class Codes: A61B 5/029 Measuring or recording blood output from the heart, e.g. minute volume A61B8/065 takes precedence
• CPC Class Codes: A61B 5/1455 using optical sensors, e.g. spectral photometrical oximeters
• CPC Class Codes: A61B 5/14552 Details of sensors specially adapted therefor
• CPC Class Codes: A61B 5/4884 inducing physiological or psychological stress, e.g. applications for stress testing
• CPC Class Codes: A61B 5/6833 Adhesive patches

Abstract

A device for non-invasively measuring at least one parameter of a cardiac blood vessel in a patient is provided. The device comprises at least one light source that emits light in the 400 nm to 1000 nm wavelength range; at least one photodetector adapted to receive light emitted by the light source and generate an output based on the received light, wherein said light is reflected from or transmitted through tissue of the patient, the output of said photodetector being correlated with a parameter of the blood vessel; and at least one probe for facilitating delivery of light from the light source to an external tissue site on the patient in the proximity of the cardiac blood vessel and receipt of light by the photodetector. A system and methods of monitoring/measuring cardiac parameters utilizing the device and/or system are also provided.

Claims

1. A system useful to determine central venous pressure in a patient comprising:

at least one light source adapted to emit light in the 400 nm to 1000 nm wavelength range;

an array of adjacent photodetectors adapted to sequentially receive light emitted by the light source and translate said light into a recordable output wherein said light is reflected from or transmitted through tissue of the patient, wherein the photodetectors are adjacent along a length of about 1.5 to 10 cm, and

at least one probe which facilitates delivery of light from the light source to an external tissue site on the patient in the proximity of the jugular vein and receipt of light reflected from or transmitted through said patient site by the photodetectors;

a signal-processing device in communication with the photodetectors adapted to translate the output from said photodetectors to determine the highest position along the vein to yield a signal and calculate therefrom central venous pressure.

2. A system as defined in claim 1, wherein the signal-processing device executes an algorithm that inverts the output from the photodetectors in order to reflect variations in blood volume or blood flow in the jugular vein and thereby yield a pressure waveform.

3. A system as defined in claim 1, wherein said light source and said photodetectors are embedded in said probe.

4. A system as defined in claim 1, comprising a plurality of light sources and a plurality of photodetectors, wherein each light source emits light that is received by a corresponding photodetector.

5. A system as defined in claim 1, comprising a plurality of probes, wherein each probe comprises at least one light source and at least one photodetector.

6. A system as defined in claim 1, wherein said probe is compatible for placement on the skin of a patient.

7. A system as defined in claim 1, wherein said signal-processing device comprises a microprocessor and a display unit.