Fluid component analysis system and method for glucose monitoring and control
First Claim
1. A patient treatment and analysis system configured to frequently measure and control the concentration of an analyte in a body fluid of a patient whose insulin sensitivity may be rapidly changing due to trauma or injury, the system comprising:
- a body fluid analyzer;
a fluid network coupled to the body fluid analyzer and configured to;
automatically and periodically draw samples of body fluid through a catheter connected to a patient; and
transport at least a portion of the samples of body fluid to the body fluid analyzer;
the body fluid analyzer configured to;
automatically and periodically measure a concentration of an analyte in the samples of body fluid; and
access an analyte history and store measured concentrations of the analyte in the analyte history; and
a treatment dosing system in communication with the fluid network and the body fluid analyzer, the treatment dosing system comprising;
a source of a treatment substance;
a treatment dosing algorithm stored in a computer memory; and
a dose delivery device configured to automatically and periodically deliver doses to the patient from the source of a treatment substance through the fluid network in response to the treatment dosing algorithm;
the treatment dosing system configured to;
use the treatment dosing algorithm to calculate an updated estimated insulin sensitivity for the patient more frequently than once per hour, the calculation achieved by accessing the analyte history and a dosage history and comparing portions of the analyte history to portions of the dosage history;
use the treatment dosing algorithm to calculate a recommended treatment dosage for the patient more frequently than once per hour, the calculation based at least in part on the updated estimated treatment sensitivity;
administer, through the dose delivery device, a dose of the treatment substance to the patient to modify the concentration of the analyte in the body fluid of the patient based at least in part on the updated estimated treatment sensitivity; and
access the dosage history and store a record of the administered dose therein.
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Accused Products
Abstract
Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient'"'"'s calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
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Citations
34 Claims
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1. A patient treatment and analysis system configured to frequently measure and control the concentration of an analyte in a body fluid of a patient whose insulin sensitivity may be rapidly changing due to trauma or injury, the system comprising:
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a body fluid analyzer; a fluid network coupled to the body fluid analyzer and configured to; automatically and periodically draw samples of body fluid through a catheter connected to a patient; and transport at least a portion of the samples of body fluid to the body fluid analyzer; the body fluid analyzer configured to; automatically and periodically measure a concentration of an analyte in the samples of body fluid; and access an analyte history and store measured concentrations of the analyte in the analyte history; and a treatment dosing system in communication with the fluid network and the body fluid analyzer, the treatment dosing system comprising; a source of a treatment substance; a treatment dosing algorithm stored in a computer memory; and a dose delivery device configured to automatically and periodically deliver doses to the patient from the source of a treatment substance through the fluid network in response to the treatment dosing algorithm; the treatment dosing system configured to; use the treatment dosing algorithm to calculate an updated estimated insulin sensitivity for the patient more frequently than once per hour, the calculation achieved by accessing the analyte history and a dosage history and comparing portions of the analyte history to portions of the dosage history; use the treatment dosing algorithm to calculate a recommended treatment dosage for the patient more frequently than once per hour, the calculation based at least in part on the updated estimated treatment sensitivity; administer, through the dose delivery device, a dose of the treatment substance to the patient to modify the concentration of the analyte in the body fluid of the patient based at least in part on the updated estimated treatment sensitivity; and access the dosage history and store a record of the administered dose therein. - View Dependent Claims (2, 3, 4, 5)
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6. A patient monitoring and dosing system, comprising:
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a body fluid analyzer configured to measure a concentration of an analyte in a sample of body fluid from a patient; and a treatment dosing system in communication with the body fluid analyzer, said treatment dosing system comprising a treatment dosing algorithm stored in a computer memory, the treatment dosing algorithm being configured to; automatically calculate an updated estimated insulin sensitivity for the patient more frequently than once per hour, the calculation based at least in part on the measured concentration of the analyte; and automatically calculate a recommended treatment dosage for the patient more frequently than once per hour, wherein the automatic calculation of the recommended treatment dosage is based at least in part on the updated estimated insulin sensitivity. - View Dependent Claims (7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A method for controlling the concentration of an analyte in a body fluid of a patient whose treatment sensitivity may be rapidly changing due to trauma or injury, the method comprising:
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automatically drawing samples of body fluid from a patient using a fluid network more frequently than once per hour; automatically transporting at least a portion of the samples of body fluid to a body fluid analyzer using the fluid network; automatically measuring a concentration of an analyte in the samples of body fluid using the body fluid analyzer; storing measured concentrations of the analyte in an analyte history stored in computer-readable memory; calculating, using one or more computer processors, an updated estimated insulin sensitivity for the patient more frequently than once per hour, wherein the calculation is achieved by accessing the analyte history and a dosage history and comparing portions of the analyte history to portions of the dosage history; calculating, using the one or more computer processors, a recommended treatment dosage for a patient more frequently than once per hour, based at least in part on the updated estimated treatment sensitivity; administering a dose of a treatment substance to the patient to modify the concentration of the analyte in the body fluid based at least in part on the updated estimated treatment sensitivity; and storing a record of the administered dose in the dosage history stored in a computer-readable memory. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27)
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28. A method for recommending dosage of a treatment substance for controlling the concentration of an analyte in a body fluid of a patient whose treatment sensitivity may be rapidly changing due to trauma or injury, the method comprising:
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automatically measuring a concentration of an analyte in samples of a body fluid using a body fluid analyzer; storing measured concentrations of the analyte in an analyte history stored in computer-readable memory; calculating, using one or more computer processors, an updated estimated insulin sensitivity for the patient more frequently than once per hour, wherein the calculation is achieved by accessing the analyte history and a dosage history and comparing portions of the analyte history to portions of the dosage history; and calculating, using the one or more computer processors, a recommended treatment dosage for a patient more frequently than once per hour, based at least in part on the updated estimated treatment sensitivity. - View Dependent Claims (29, 30, 31, 32, 33, 34)
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Specification