Hepatic electrical stimulation

• US 8,417,331 B2
• Filed: 01/19/2011
• Issued: 04/09/2013
• Est. Priority Date: 06/14/2007
• Status: Active Grant

• Current Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Original Assignee: Board of Regents of the University of Texas System (University of Texas System)
• Inventors: Pasricha, Pankaj Jay, Chen, Jiande
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): KIMBALL, JEREMIAH T
• Application Number:
  US13/009,086
• Publication Number:
  US 20110118747A1
• Time in Patent Office: 811 Days
• Field of Search: 607/2
• US Class Current: 607/2
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control

Abstract

The present invention relates to a method of providing electrical stimulation to a liver of a subject which includes providing one or more stimulatory electrodes to the liver of the subject and providing electrical stimulation to the liver of the subject. The invention further relates to methods of reducing risk factors of metabolic syndrome, treating diabetes, treating a subject having eating disorders and reducing glucose levels of a subject using methods of the present invention.

Claims

1. A method for detecting levels of one or more risk factors of a metabolic syndrome, the method comprising:

inserting an end of a needle having an interior bore from the exterior of a subject onto or into a liver parenchyma;

inserting a stimulatory electrode through the interior bore of the needle until the electrode engages the liver parenchyma; and

removing the needle;

wherein the electrode remains on or in the liver parenchyma, and wherein the electrode is operatively connected to a sensor to provide electrical stimulation to the subject based on one or more risk factors detected by the sensor.

2. The method of claim 1, wherein the one or more risk factors of a metabolic syndrome are glucose levels more than about 110 mg/dL, obesity, insulin resistance, levels of serum triglycerides more than about 150 mg/dL, serum HDL cholesterol levels less than about 50 mg/dL, or blood pressure levels more than about 130/85 mmHg.

3. The method of claim 1, wherein the sensor detects one or more of plasma glucose, serum triglycerides, serum HDL, and blood pressure.

4. The method of claim 3, wherein the sensor is configured to provide feedback to the operatively connected electrode for adjustment of stimulation relative to levels of risk factors for a metabolic syndrome.