Corpus callosum neuromodulation assembly

• US 8,417,345 B2
• Filed: 03/04/2010
• Issued: 04/09/2013
• Est. Priority Date: 05/04/2004
• Status: Active Grant

• Current Assignee: Cleveland Clinic Foundation
• Original Assignee: Cleveland Clinic Foundation
• Inventors: Machado, Andre, Rezai, Ali R.
• Primary Examiner(s): Schaetzle, Kennedy
• Application Number:
  US12/717,632
• Publication Number:
  US 20100185269A1
• Time in Patent Office: 1,132 Days
• Field of Search: None
• US Class Current: 607/46
• CPC Class Codes: A61N 1/0531 Brain cortex electrodes
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/0539 Anchoring of brain electrode systems, e.g. within burr hole
• CPC Class Codes: A61N 1/3605 Implantable neurostimulators for stimulating central or peripheral nerve system
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease

Abstract

Neuromodulation assemblies with lead bodies having curvatures that mimic the curvatures of the splenium, trunk, genu, or rostrum of the corpus callosum. Methods of stimulating the corpus callosum and methods of securing an electrical lead in the brain are also provided.

Claims

1. A neuromodulation assembly comprising:

a lead body having a top surface and a bottom surface, the lead body having a curvature that mimics the curvature of the trunk, genu, splenium, or rostrum of the corpus callosum in an operative position of the lead body;

an electrical contact exposed at the bottom surface and not the top surface of the lead body;

a conductor coupled to the electrical contact and extending from the lead body;

an accessory strand extending from the lead body; and

an anchor disposed on the accessory strand.

2. The neuromodulation assembly of claim 1, wherein the lead body has a curvature that mimics the curvature of the trunk of the corpus callosum in an operative position of the lead body.

3. The neuromodulation assembly of claim 1, wherein the conductor extends from substantially the center of the lead body.

4. The neuromodulation assembly of claim 1, wherein the lead body has a curvature that mimics the curvature of the rostrum of the corpus callosum in an operative position of the lead body.

5. The neuromodulation assembly of claim 1, wherein the lead body has a curvature that mimics the curvature of the splenium of the corpus callosum in an operative position of the lead body.

6. The neuromodulation assembly of claim 1, wherein the lead body has a curvature that mimics the curvature of the genu of the corpus callosum in an operative position of the lead body.

7. The neuromodulation assembly of claim 1, wherein the lead body is fabricated from a flexible material and is deformable from a pre-operative position to the operative position and is configured to retain its shape when in the operative position.

8. The neuromodulation assembly of claim 7, wherein the material is a shape memory alloy.

9. The neuromodulation assembly of claim 1, wherein the anchor comprises a plurality of anchors.

10. The neuromodulation assembly of claim 1, wherein the anchor is selected from the group consisting of:

a tine, a hook, and a suture sleeve.

11. The neuromodulation assembly of claim 1, wherein the anchor is slidably disposed on the accessory stand.

12. The neuromodulation assembly of claim 1, wherein the lead body further comprises a fastener.

13. The neuromodulation assembly of claim 12, wherein the fastener comprises a pair of fasteners.

14. An electrical stimulation kit comprising the neuromodulation assembly of claim 13, and further comprising an installation tool having a proximal portion comprising a handle and a distal portion comprising a pair of arms that are connected by a first pivot, the pair of arms having distal ends configured to releasably cooperate with the pair of fasteners of the lead body.

15. The electrical stimulation kit of claim 14, wherein the installation tool further comprises a second pivot connecting the pair of arms, the second pivot located proximal to the first pivot.

16. The electrical stimulation kit of claim 14, wherein the pair of fasteners of the lead body comprise male fasteners and the distal ends of the pair of arms comprise female fasteners, the male and female fasteners acting in cooperation with each other to secure the installation tool to the lead body.

17. The neuromodulation assembly of claim 12, wherein the fastener comprises a male fastener for cooperation with a female fastener.

18. The neuromodulation assembly of claim 12, wherein the fastener comprises a strap, a groove, a buckle, a through-hole, or a snap.

19. The neuromodulation assembly of claim 1, wherein the accessory strand comprises a plurality of accessory strands.

20. The neuromodulation assembly of claim 19, wherein each of the plurality of accessory strands has at least one anchor disposed thereon.

21. The neuromodulation assembly of claim 1, wherein the curvature is a preset curvature which the lead body is configured to retain.

22. The neuromodulation assembly of claim 1, wherein the lead body has a J-shaped curvature in the operative position of the lead body.

23. The neuromodulation assembly of claim 1, wherein the lead body has a cambered curvature in the operative position of the lead body.

24. A method of stimulating a corpus callosum, the method comprising:

placing an electrical lead having an electrode disposed thereon in communication with a corpus callosum; and

activating the electrode to apply an electrical signal to the corpus callosum to stimulate the corpus callosum;

wherein;

the electrical lead comprises;

a lead body that includes a top surface, a bottom surface, and a curvature that mimics a curvature of the trunk, genu, splenium, or rostrum of the corpus callosum in an operative position of the lead body; and

an electrical contact exposed at the bottom surface and not the top surface of the lead body;

a conductor is coupled to the electrical contact and extends from the lead body;

an accessory strand extends from the lead body; and

an anchor is disposed on the accessory strand.

25. The method of claim 24, wherein the electrode comprises a plurality of electrodes.

26. The method of claim 24, wherein the electrical lead penetrates the corpus callosum.

27. The method of claim 24, wherein the electrical lead is delivered to the corpus callosum intravascularly.

28. The method of claim 24, wherein the corpus callosum includes an under-surface and the electrical lead is placed on the under-surface of the corpus callosum.

29. A method of securing in the brain an electrical lead, the method comprising:

anchoring the electrical lead to the dura mater of the brain;

wherein;

the electrical lead comprises;

a lead body that includes a top surface, a bottom surface, and a curvature that mimics a curvature of the trunk, genu, splenium, or rostrum of the corpus callosum in an operative position of the lead body; and

an electrical contact exposed at the bottom surface and not the top surface of the lead body;

a conductor is coupled to the electrical contact and extends from the lead body;

an accessory strand extends from the lead body; and

an anchor is disposed on the accessory strand.

30. The method of claim 29, wherein the dura mater is the dura mater of the convexity.

31. The method of claim 29, wherein the dura mater is the dura mater of the falx.